A New Pentanorlanostane Derivative, Cladosporide A, as a Characteristic Antifungal Agent against Aspergillus fumigatus, Isolated form Cladosporium sp.

概要

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In the course of searching for new antifungal agents, a new pentanorlanostane derivative, cladosporide A(1), was isolated along with ergosterol, ergosterol peroxide and 23,24,25,26,27-pentanorlanost-8-ene-3β, 22-diol(2) form Cladosporium sp. as a characteristic antifungal agent against the human pathogenic filamentous fungus Aspergillus fumigatus. The structure of 1 was established as 3β, 22-dihydroxy-23,24,25,26,27-pentanorlanostane-29-al by spectroscopic and chemical investigation and X-ray crystallographic analysis. Inhibitory activity against A. fumigatus (IC_<80>0.5-4.0 μg/ml) was observed for cladosporide A (1), but bo activity was observed against pathogenic yeasts, Candida albicans and Cryptococcus neoformans, and other parhogenic filamentous fungi, Aspergillus niger and A. flavus. The 4β-aldehyde residue in 1 might be essential for the antifungal activity, since 23,24,25,26,27-pentanorlanost-8-ene-3β, 22-diol (2) showed no inhibition against the above four fungi.
公益社団法人日本薬学会の論文
2000-10-01