Inhibitory Effects of Methyl Brevifolincarboxylate Isolated from Phyllanthus niruri L. on Platelet Aggregation(Pharmacognosy)

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概要

• 論文の詳細を見る

• A platelet-aggregatory inhibitor was isolated from the 50% MeOH extract of Phyllanthus niruri L. leaf. Its structure was determined to be methyl brevifolincarboxylate on the basis of the ^1H-, ^<13>C-NMR, and high-resolution mass spectral data. We compared the antiplatelet aggregatory effects of the constituent with adenosine, a well-known inhibitor of platelet aggregation. Platelet aggregation was induced by collagen or adenosine 5'-diphosphate as an activating agent; the extent of inhibition was monitored with a platelet aggregometer employing a laser-scattering method. The inhibitory effects of methyl brevifolincarboxylate were found to be as potent as adenosine that is known to act on an A_<2A> subtype receptor.

• 社団法人日本薬学会の論文
• 2007-02-01

著者

• Itabashi Takeshi

  Faculty of Pharmaceutical Sciences, Hoshi University

• Moriyama Hiroyoshi

  Faculty Of Pharmaceutical Sciences Hoshi University:laboratory Of Pharmacotherapeutics Showa Pharmac

• IIZUKA Toru

  Faculty of Pharmaceutical Sciences, Hoshi University

• MORIYAMA Hiroyoshi

  Pharmcotherapeutics Laboratory, Showa Pharmaceutical University

• NAGAI Masahiro

  Faculty of Pharmaceutical Sciences, Hoshi University

• TANIGUCHI Akemi

  Pharmacotherapeutics Laboratory, Showa Pharmaceutical University

• HOSHI Keiko

  Pharmacotherapeutics Laboratory, Showa Pharmaceutical University

• Iizuka Toru

  Laboratory Of Pharmacognosy Yokohama College Of Pharmacy

• Iizuka Toru

  Faculty Of Pharmaceutical Sciences Hoshi University

• Hoshi K

  Laboratory Of Pharmacotherapeutics Showa Pharmaceutical University

• Nagai M

  Faculty Of Pharmaceutical Sciences Hoshi University

• Nagai Masahiro

  Department Of Medicinal Plant Sciences Hoshi University

• Nagai M

  Hoshi Univ. Tokyo Jpn

• Nagai Masahiro

  Faculty Of Pharmaceutical Sciences Hoshi University

• Taniguchi Akemi

  Pharmacotherapeutics Laboratory Showa Pharmaceutical University

• Ishizaki Takayuki

  Tamagawa University Research Institute

• Hoshi Katsuji

  Laboratory Of Pharmacotherapeutics Showa Pharmaceutical University

• Nagai Makoto

  Faculty Of Pharmaceutical Sciences Hoshi University

• Itabashi T

  Waseda Univ. Tokyo Jpn

• Nagai Masahiro

  Faculty Of Human Environments Studies The University Of Human Environments

• NAGAI Masahiro

  Faculty of Human Environment, University of Human Environments

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