Effects of Fukinolic Acid and Cimicifugic Acids from Cimiclfuga Species on Collagenolytic Activity
スポンサーリンク
概要
- 論文の詳細を見る
The inhibitory collagenolytic activity(47-64% inhibition in 0.22-0.24 μM)of fukinolic acid and cimicifugic acids A, B, and C, which are esters of fukiic acid(3', 4'-dihydroxybenzyl tartaric acid)was more potent than that(20-37% inhibition in 0.23-0.24 μM)of cimicifugic acids D, E, F, which are esters of pscidic acid(4'-hydroxybenzyl tartaric acid). Since fukiic acid showed weaker inhibition, and caffeic acid, ferulic acid, isoferulic acid, and p-coumaric acid showed far weaker activities, the entire structures of fukinolic acid and cimicifugic acids A, B, and C proved to be responsible for the inhibitory activities. Trypsin and pronase E hydrolyzed collagen nonselectively alone or in addition to collagenase. These collagenolytic activities were also inhibited by fukinolic acid. These results show that fukinolic acid may inhibit either the collagenolytic activities specific to collagenase or nonspecific to other emzymes. The present studies suggest the potential effect of fukinolic acid and cimicifugic acids of Cimicifuga rhizomes in preventing collagen degradation by collagenases or collgenolytic enzymes under pathological conditions, wound healing, or inflammation.
- 公益社団法人日本薬学会の論文
- 2001-10-01
著者
-
草野 昭子
Osaka University of Pharmaceutical Sciences
-
Kusano Akiko
Osaka University Of Pharmaceutical Sciences
-
SHIBANO Makio
Osaka University of Pharmaceutical Sciences
-
KUSANO Genjiro
Osaka University of Pharmaceutical Sciences
-
Shibata M
Fumakilla Ltd.
-
NAGAI Masahiro
Faculty of Pharmaceutical Sciences, Hoshi University
-
Nagai M
Faculty Of Pharmaceutical Sciences Hoshi University
-
Nagai Masahiro
Department Of Medicinal Plant Sciences Hoshi University
-
Nagai M
Hoshi Univ. Tokyo Jpn
-
Nagai Masahiro
Faculty Of Pharmaceutical Sciences Hoshi University
-
SEYAMA Yoshiyuki
Faculty of Pharmaceutical Sciences, Hoshi University
-
Kusano G
Osaka University Of Pharmaceutical Sciences
-
Seyama Y
Faculty Of Pharmaceutical Sciences Hoshi University
-
Kusano Genjiro
Osaka University Of Phamaceutical Sciences
-
Nagai Masahiro
Faculty Of Human Environments Studies The University Of Human Environments
-
Kusano A
Osaka University Of Pharmaceutical Sciences
-
NAGAI Masahiro
Faculty of Human Environment, University of Human Environments
関連論文
- Studies on the Constituents of Cimicifuga Species. XVII. Four New Glycosides from the Aerial Parts of Cimicifuga simplex WORMSK.
- Studies on the Constituents of Cimicifuga Species. XVI.Three New Cycloartane Xylosides from the Aerial Parts of Cimicifuga simplex WORMSKJORD
- Studies on the Constituents of Cimicifuga Species. XIV. A New Xyloside from the Aerial Parts of Cimicifuga simplex WORMSK.
- Studies on the Constituents of Cimicifuga Species. XX. Absolute Stereostructures of Cimicifugoside and Actein from Cimicifu simplex WORMSK.
- Fibrinolytic activity of ligustilide and pharmaceutical comparison of Angelica acutiloba roots before and after processing in hot water
- Quality of Angelica acutiloba roots cultivated and processed in Sichuan province of China
- Melanogenesis Stimulation in Murine B16 Melanoma Cells by Umberiferae Plant Extracts and Their Coumarin Constituents(Pharmacognosy)
- Vasorelaxant Effects of Acer nikoense Extract and Isolated Coumarinolignans on Rat Aortic Rings(Pharmacognosy)
- Inhibitory Effects of Methyl Brevifolincarboxylate Isolated from Phyllanthus niruri L. on Platelet Aggregation(Pharmacognosy)
- Vasorelaxant Effects of Methyl Brevifolincarboxylate from the Leaves of Phyllanthus niruri(Pharmacognosy)
- Antiplatelet Aggregatory Effects of the Constituents Isolated from the Flower of Carthamus tinctorius
- Adenine, an Inhibitor of Platelet Aggregation, from the Leaves of Cassia alata(Pharmacognosy)
- Platelet Aggregatory Effects of Nasturtium officinale and Solanum torvum Extracts
- Antiplatelet Aggregating Activity of Extracts of Indonesian Medicinal Plants I
- A Stabilized Flavonoid Glycoside in Heat-Treated Cassia alata Leaves and Its Structural Elucidation
- Studies on the Constituents of Cimicifuga Species. XV.Two New Diglycosides from the Aerial Parts of Cimicifuga simplex WORMSK.
- The Effectiveness of a Web Bulletin Board Enhanced with a Knowledge Map
- Studies on the Constituents of Broussonetia Species. VII. Four New Pyrrolidine Alkaloids, Broussonetines M, O, P, and Q, as Inhibitors of Glycosidase, from Broussonetia kazinoki SIEB.
- Chemical studies on the root of Heracleum candicans WALL
- Antioxidant constituents in the dayflower (Commelina communis L.) and their α-glucosidase-inhibitory activity
- Coumarins from the roots of Ligusticum multivittatum
- Two Isocoumarins from Pleurospermum angelicoides
- Four Coumarins from Heracleum yunngningense
- Three New Saponins as Index Compounds of Glycyrrhiza flavescens BOISS. Growing in Turkey
- Biological Activity of α-Thujaplicin, the Isomer of Hinokitiol(Biochemistry/Molecular Biology)
- Biological Activity of Tropolone(Biochemistry/Molecular Biology)
- Antifungal Activity of Hinokitiol-Related Compounds on Wood-Rotting Fungi and Their Insecticidal Activities
- Anti-tumor Promoting Activities of Isoflavonoids from Wistaria brachybotrys
- Two Novel Diarylheptanoid Glucosides from Myrica gale var. tomentosa and Absolute Structure of Plane-Chiral Galeon
- Synthesis and Serotonin 2 (5-HT_2) Receptor Antagonist Activity of 5-Aminoalkyl-Substituted Pyrrolo[3,2-c]azepines and Related Compounds
- Zonisamide Increases Dopamine Turnover in the Striatum of Mice and Common Marmosets Treated With MPTP
- Effects of Fukinolic Acid and Cimicifugic Acids from Cimiclfuga Species on Collagenolytic Activity
- Vasoactive Effects of Cimicifugic Acids C and D, and Fukinolic Acid in Cimicifuga Rhizome
- Three New Fukiic Acid Esters, Cimicifugic Acids A, B and C, from Cimicifuga Simplex WORMSK.
- Effect of the Adhesive Layer Thichness on the Fracture Toughness of Dental Adhesive Resins
- Inhibition of LysoPAF Acetyltransferase by the Ingredients from Lithospermum Root
- Inhibition of LysoPAF Acetyltransferase Activity by Components of Licorice Root
- Studies on the Constituents of Broussonetia Species. V. Two New Pyrrolidine Alkaloids, Broussonetines K and L, as Inhibitors of Glycosidase, from Broussonetia Kazinoki SIEB.
- Studies on the Antioxidant Active Constituents of the Dried Powder from Bidens polosa L. var. radiata SCH.
- Two New Pyrrolidine Alkaloids, Broussonetines Y and Z from Broussonetia kazinoki SIEB. and Activity of Glycosidases Inhibition by N-Alkylation of Broussonetines
- Polyhydroxylated Alkaloids with Lipophilic Moieties as Glycosidase Inhibitors from Higher Plants
- Studies on the Constituents of Broussonetia Species X.Six New Alkaloids from Broussonetia kazinoki SIEB.
- Determination of 1-Deoxynojirimycin and 2, 5-Dihydroxymethy13, 4-dihydroxypyrrolidine Contents of Commelina communis var. hortensis and The Antihyperglycemic Activity
- Two New Pyrrolidine Alkaloids, Radicanmines A and B, as Inhibitors of α-Glucosidase from Lobelia chinensis LOUR.
- The Biosynthesis of Broussonetines : Origin of the Carbon Skeleton
- Studies on the Constituents of Broussonetia Species VIII. Four New Pyrrolidine Alkaloids, Broussonetines R, S, T, and V and a New Pyrroline Alkaloid, Broussonetine U, from Broussonetia kazunoki SIEB.^
- Studies on the Constituents of Cimicifuga Species.XXVIII.^ Four New Cycloart-7-enol Glycosides from the Underground Parts of Cimicifuga simplex WORMSK
- Studies on the Constituents of Cimicifuga Species. XXVII. Malonyl Cyclolanostanol Glycosides from the Underground Parts of Cimicifuga simplex WORMSK.
- A New Pyrrolizidine Alkaloid, Broussonetine N, as an Inhibitor of Glycosidase, from Broussonetia kazinoki SIBE. and Absolute Stereostructures of Broussonetines A and B
- Studies on the Constituents of Cimicifuga Species. XXVI. Twelve New Cyclolanostanol Glycosides from the Underground Parts of Cimicifuga simplex WORMSK.
- Studies on Inhibitory Activities of Fukiic Acid Esters on Germination, α-Amylase and Carboxypeptidase A
- Antimalarial Activity and Nucleoside Transport Inhibitory Activity of the Triterpenic Constituents of Cimicifuga spp.
- Studies on the Constituents of Cimicifuga Species. XXI. Two New Cyclolanostanol Xylosides, Bugbanosides A and B from Cimicifuga simplex WORMSK.
- In Vitro Study for Inhibition of NO Production about Constituents of Sappan Lignum(Pharmacognosy)
- Phenolic Glycosides from Eupatorium fortunei Turcz
- Saikosaponin Homologues from Verbascum spp. The Structures of Mulleinsaponins I-VII
- Studies on Antihypertensive Agents with Antithrombotic Activity.2.Syntheses and Pharmacological Evaluation of Pyrrolo[2,3-c]azepine Derivatives
- Synthesis and Pharmacological Evaluation of Pyrroloazepine Derivatives as Potent Antihypertensive Agents with Antiplatelet Aggregation Activity
- Studies on the Constituents of Broussonetia Species. IV. Two New Pyrrolidinyl Piperidine Alkaloids, Broussonetines I and J, from Broussonetia kazinoki SIEB.
- Sensitive Spectrophotometric Determination of Phosphate Using Silica-Gel Collectors
- Studies on the Constituents of Broussonetia Species. III. Two New Pyrrolidine Alkaloids, Broussonetines G and H, as Inhibitors of Glycosidase, from Broussonetia kazinoki SIEB.
- Studies on the Constituents of Broussonetia Species. II. Six New Pyrrolidine Alkaloids, Broussonetine A, B, E, F and Broussonetinine A and B, as Inhibitors of Glycosidases from Broussonetia kazinoki SIEB.
- Phylogenetic Relationship of Six Glycyrrhiza Species Based on rbcL Sequences and Chemical Constituents
- Bone Resorption Inhibitors from Hop Extract
- Oleanane Acid from Myrica cerifera
- Studies on the Constituents of Aceraceae Plants. XIII. Diarylheptanoids and Other Phenolics from Acer nikoense
- Studies on Index Compounds for HPLC Analysis of Glycyrrhiza flavescens Growing in Turkey
- Studies on the Constituents of Broussonetia Species. I. Two New Pyrrolidine Alkaloids, Broussonetines C and D, as β-Galactosidase and β-Mannosidase Inhibitors from Broussonetia kazinoki SIEB.
- Five New Nortropane Alkaloids and Six New Amino Acids from the Fruit of Morus alba LINNE Growing in Turkey
- Three Trihydroxypiperidines, Glycosidase Inhibitors, from Eupatorium fortunei TURZ
- Studies on the Constituents of cimicifuga Species. XIX. Eight New Glycosides from Cimicifuga simplex WORMSK.
- Studies on the Constituents of Cimicifuga Species. XVIII. Four New Xylosides from the Aerial Parts of Cimicifuga simplex WORMSK.
- Chemical studies on the root of Heracleum candicans Wall. (Part 3)
- Phenolic Glycosides from Eupatorium fortunei Turcz.
- Determination of 1-Deoxynojirimycin and 2, 5-Dihydroxymethyl 3, 4-dihydroxypyrrolidine Contents ofCommelina communis var. hortensis and The Antihyperglycemic Activity
- Three New Saponins as Index Compounds of Glycyrrhiza flavescens BOISS. Growing in Turkey
- Phenolic Constituents of Cimicifuga Species Rhizomes.
- Studies on the Antioxidant Active Constituents of the Dried Powder from Bidenspilosa L. var. radiata SCH.
- Two New Pyrrolidine Alkaloids, Broussonetines Y and Z from Broussonetia kazinoki SIEB. and Activity of Glycosidases Inhibition by N-Alkylation of Broussonetines
- Studies on Index Compounds for HPLC Analysis of Glycyrrhiza flavescens Growing in Turkey
- Antiplatelet Aggregating Activity of Extracts of Indonesian Medicinal Plants I
- Two New Flavonol Glycosides from Morettia philaena Growing in Egypt
- Antiplatelet Aggregatory Effects of the Constituents Isolated from the Flower of Carthamus tinctorius
- Platelet Aggregatory Effects of Nasturtium officinale and Solanum torvum Extracts
- Five condensed furanocoumarins from the root of Heracleum candicans Wall
- Four novel furanocoumarin glucosides, candinosides A, B, C and D, from Heracleum candicans Wall
- STUDIES ON INDEX COMPOUNDS FOR HPLC ANALYSIS OF GLYCYRRHIZA GLABRA
- Flavonoid Glycosides, α-Glucosidase Inhibitors, from Leaves of Zizyphus jujuba MILL. var. inermis REHD.(Natural Medicine Note)
- Three Trihydroxypiperidines, Glycosidase Inhibitors, from Eupatorium fortunei TURZ
- Phenolic Constituents of Lycopus lucidus(Natural Medicine Note)
- Studies on Index Compounds for HPLC Analysis of Glycyrrhiza macedonica
- Inhibition of LysoPAF Acetyltransferase by the Ingredients from Lithospermum Root
- Studies on the Constituents of Aceraceae Plants (X) : Isolation of Flavonoid Glycosides and a Cerebroside from the Leaves of Acer negundo
- Studies on the Constituents of Aceraceae Plants. IX. : Constituents of Acer cissifolium
- Two New Triterpenic Glucosidates from Lavandula coronipifolia in Egypt
- Seasonal Changes in Water Quality of Rivers and Ground Water in Karakalpakstan, Uzbekistan
- Characterization of a Glycyrrhizin-Deficient Strain of Glycyrrhiza uralensis
- Bio-imaging of hydroxyl radicals in plant cells using the fluorescent molecular probe rhodamine B hydrazide, without any pretreatment(PLANT BIOTECHNOLOGY)