Antimalarial Activity and Nucleoside Transport Inhibitory Activity of the Triterpenic Constituents of Cimicifuga spp.
スポンサーリンク
概要
- 論文の詳細を見る
The in vitro antimalarial activity against human malaria parasite (Plasmodium falciparum, FCR-3 strain) was examined using 59 triterpenoids obtained during studies on teh triterpenic constituents of Cimicifuga spp. The 50% effective concentration values (EC_<50>) of 25 active triterpenoids were 1.0-3.0 μM, and 19 of the compounds had a common 16,23 : 23,26 : 24,25-triepoxy group in the side-chain moieties. Among the active triterpenoids. 9 also showed significant inhibition of nucleoside transport in mouse spleocytes A relationship between the antimalarial, activity and the inhibition of nucleoside transport involving these triterpenoids is discussed.
- 公益社団法人日本薬学会の論文
- 1998-08-15
著者
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草野 昭子
Osaka University of Pharmaceutical Sciences
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Kusano Akiko
Osaka University Of Pharmaceutical Sciences
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TAKAHIRA Masayuki
Osaka University of Pharmaceutical Sciences
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SHIBANO Makio
Osaka University of Pharmaceutical Sciences
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KUSANO Genjiro
Osaka University of Pharmaceutical Sciences
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Shibata M
Fumakilla Ltd.
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KIM Hye-Sook
Faculty of Pharmaceutical Sciences, Okayama University
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WATAYA Yusuke
Faculty of Pharmaceutical Sciences, Okayama University
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SUZUKI Ryuji
Shionogi Research Laboratories, Shionogi & Co., Ltd.
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KOIZUMI Kenzo
Shionogi Research Laboratories, Shionogi & Co., Ltd.
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Koizumi K
Mukogawa Women's Univ. Nishinomiya Jpn
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Koizumi Kenzo
Shionogi Research Laboratories Shionogi & Co. Ltd.
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Kim Hye-sook
Faculty Of Pharmaceutical Sciences Okayama University
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TAKAHARA Masayuki
Osaka University of Pharmaceutical Sciences
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Kusano G
Osaka University Of Pharmaceutical Sciences
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Kusano Genjiro
Osaka University Of Phamaceutical Sciences
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Wataya Yusuke
Faculty Of Pharmaceutical Sciences Okayama University
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Suzuki Ryuji
Shionogi Institute For Medical Science
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Wataya Yusuke
Faculty Of Pharmaceutical Science Graduate School Of Medicine Dentistry And Pharmaceutical Science O
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Kusano A
Osaka University Of Pharmaceutical Sciences
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Kim Hye-Sook
Faculty of Pharmaceutical Science, Graduate School of Medicine, Dentistry and Pharmaceutical Science, Okayama University
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