Synthesis of Novel Conjugates of Tetraoxane Endoperoxide with Bis(Quaternary Ammonium Salts)
スポンサーリンク
概要
- 論文の詳細を見る
Novel water-soluble conjugates of 1,2,4,5-tetraoxane bis(quaternary ammonium salts) were synthesized in a relatively stable crystalline form via four steps starting from methyltrioxorhenium-catalyzed endo-peroxidation of ethyl 4-oxocyclohexanecarboxylate with hydrogen peroxide in hexafluoro-2-propanol. The assay for the in vitro toxicity of water-soluble tetraoxanes 5a–5d to malaria parasites indicate that they were inactive against the Plasmodium falciparum FCR-3 strain.
著者
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KIM Hye-Sook
Faculty of Pharmaceutical Sciences, Okayama University
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WATAYA Yusuke
Faculty of Pharmaceutical Sciences, Okayama University
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IZUMI Minoru
Division of Bioscience, Graduate School of Natural Science and Technology, Okayama University
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NAKAJIMA Shuhei
Division of Bioscience, Graduate School of Natural Science and Technology, Okayama University
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BABA Naomichi
Division of Bioscience, Graduate School of Natural Science and Technology, Okayama University
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Kumura Naokazu
Division Of Bioscience Graduate School Of Natural Science And Technology Okayama University
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KOBAYASHI Michiyo
Division of Bioscience, Graduate School of Natural Science and Technology, Okayama University
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FURUKAWA Hirotaka
Division of Bioscience, Graduate School of Natural Science and Technology, Okayama University
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ONYANGO Arnold
Department of Food Science and Postharvest Technology, Jomo Kenyatta University of Agriculture and T
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