Antimalarial Activity of Lavandulyl Flavanones Isolated from the Roots of Sophora flavescens (Pharmacognosy)
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概要
- 論文の詳細を見る
Four lavandulyl flavanones, (2S)-2'-methoxykurarinone (1), sophoraflavanone G (2), leachianone A (3), and (-)-kurarinone (4), which are isolated from the roots of Sophora flavescens have been tested for in vitro antimalarial activity against Plasmodium falciparum. Compounds 1-3 showed moderate antimalarial activities with EC_<50> values of 2.4×10^<-6>, 2.6×10^<-6>, and 2.1×10^<-6>M, respectively. These compounds did not show selective toxicity against P. falciparum in the toxicity test on mouse mammalian tumor cells, however, it is suggested that the position of methoxyl groups in flavanone skeleton plays an important role on antimalarial activity.
- 公益社団法人日本薬学会の論文
- 2004-05-01
著者
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KIM Yong
Department of Metallurgy and Materials Science, Hanyang University
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Sohn Dong
韓国
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Sohn Dong
Department Of Pharmacy College Of Pharmacy Wonkwang University
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Sohn Dong
Medicinal Resources Research Center College Of Pharmacy Wonkwang University
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Sohn Dong
College Of Pharmacy Medicinal Resources Research Center Wonkwang University
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Kang Tai
College Of Pharmacy Wonkwang University
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Kang Tai
韓国
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Kim Hye-sook
岡山大学 薬学部
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Park Hyun
Department of Systems Innovation, Graduate School of Engineering, The University of Tokyo
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Sohn D
College Of Pharmacy Wonkwang University
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Chang Jong-duk
Department Of The Third Medicine Professional Graduate School Of Oriental Medicine Wonkwang Universi
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Kim Yong
Department Of Parasitology College Of Medicine Wonkwang University
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Kim Youn
College Of Pharmacy Wonkwang University
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KIM Hye-Sook
Faculty of Pharmaceutical Sciences, Okayama University
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WATAYA Yusuke
Faculty of Pharmaceutical Sciences, Okayama University
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Kim M
Kunsan National Univ. Chonbuk Kor
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Kim Hye-sook
Faculty Of Pharmaceutical Sciences Okayama University
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Kjm Myung
Life Sciences Division Korea Institute Of Science And Technology
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Wataya Y
Faculty Of Pharmaceutical Sciences Okayama University
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Wataya Yusuke
Fac. Of Pharmaceutical Sci. Graduate School Of Medicine Dentistry And Pharmaceutical Sci. Okayama Un
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KIM Myung
Life Sciences Division, Korea Institute of Science and Technology
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LEE Geon-Mok
Department of the Third Medicine, Professional Graduate School of Oriental Medicine, WonKwang Univer
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Kim Myung
Life Sciences Division Korea Institute Of Science And Technology
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Park Hyun
Department Of Computer Science Korea Advanced Institute Of Science & Technology
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Lee Geon-mok
Department Of The Third Medicine Professional Graduate School Of Oriental Medicine Wonkwang Universi
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Kim H‐s
Okayama Univ. Okayama Jpn
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Kim Yong
Department And Research Institute Of Rehabilitation Medicine Yonsei University College Of Medicine
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Shin Dong-won
Department Of Oriental Medicine Resources College Of Bio Industry Science Sunchon National Universit
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Wataya Yusuke
Faculty Of Pharmaceutical Science Graduate School Of Medicine Dentistry And Pharmaceutical Science O
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Shin Dong-young
Department Of Development In Plant Resources College Of Bio Industry Science Sunchon National Univer
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Park H
Department Of Sport Medicine Kyung-hee University
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Park Hyun
Department Of Computer Science Chungnam National University
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Park Hyun
Department Of Chemical & Biomolecular Engineering Korea Advanced Institute Of Science & Tech
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Park Hyun
Department Of Ceramic Engineering Chonnam National University
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Park Hyun
Department of Biotechnology, Yeungnam University
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Kim Hye-Sook
Faculty of Pharmaceutical Science, Graduate School of Medicine, Dentistry and Pharmaceutical Science, Okayama University
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