Berberine, a Natural Product, Combined with Cisplatin Enhanced Apoptosis through a Mitochondria/Caspase-Mediated Pathway in HeLa Cells(Analytical Biochemistry)
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概要
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Berberine, a main component of Coptidis Rhizoma, has been extensively studied and is known to exhibit multiple pharmacologic activities. In this study, we investigated whether the combination of berberine and cisplatin exhibited significant cytotoxicity in HeLa cells. Apoptosis was evaluated based on DNA fragmentation and cytofluorometrically with the annexin-V/propidium iodide labeling method. Combined treatment with berberine and cisplatin acted in concert to induce loss of mitochondrial membrane potential (ΔΨ_m), release of cytochromec from mitochondria, and decreased expression of antiapoptotic Bcl-_2, Bcl-_<x/L>, resulting in activation of caspases and apoptosis. Further study showed that cell death induced by the combined treatment was associated with increased reactive oxygen species generation and lipid peroxidation. Moreover, we discovered that the combined treatment-induced apoptosis was mediated by the activation of the caspase cascade. These results indicated that the potential of cytotoxicity mediated through the mitochondria-caspase pathway is primarily involved in the combined treatment-induced apoptosis.
- 公益社団法人日本薬学会の論文
- 2008-05-01
著者
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KIM Yong
Department of Metallurgy and Materials Science, Hanyang University
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Lee Jeong-ho
Vestibulocochlear Research Center And Department Of Microbiology Wonkwang University
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Lee Jeong-ho
韓国
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LEE Jeong-Han
VestibuloCochlear Research Center of Wonkwang University
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SO Hong-seob
VestibuloCochlear Research Center of Wonkwang University
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YOUN Myung-Ja
VestibuloCochlear Reserch Center and Department of Microbiology, School of Medicine, Wonkwang Univer
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PARK Raekil
VestibuloCochlear Reserch Center and Department of Microbiology, School of Medicine, Wonkwang Univer
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CHO Hea-Joong
Department of Obstetrical& Gynecological Surgery, Wonkwang Medical Center, Wonkwang University
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KIM Hyung-Jin
VestibuloCochlear Research Center and Department of Microbiology, Wonkwang University
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KIM Yunha
VestibuloCochlear Research Center and Department of Microbiology, Wonkwang University
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SOHN Jung
VestibuloCochlear Research Center and Department of Microbiology, Wonkwang University
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CHUNG Sang-Young
Department of Surgery, Chonnam National University Medical School
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Sohn Jung
Vestibulocochlear Research Center And Department Of Microbiology Wonkwang University
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Cho Hea-joong
Department Of Obstetrical& Gynecological Surgery Wonkwang Medical Center Wonkwang University
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Chung Sang-young
Department Of Surgery Chonnam National University Medical School
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So Hong-seob
Vestibulocochlear Research Center And Department Of Microbiology Wonkwang University
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Park Raekil
Vestibulocochlear Res. Center And Dep. Of Microbiology School Of Medicine Wonkwang Univ.
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Park Raekil
Vestibulocochlear Research Center And Department Of Microbiology Wonkwang University
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Youn Myung-ja
Vestibulocochlear Research Center And Department Of Microbiology Wonkwang University
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Kim Yunha
Vestibulocochlear Research Center And Department Of Microbiology Wonkwang University
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Kim Yong
Department And Research Institute Of Rehabilitation Medicine Yonsei University College Of Medicine
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Kim Hyung-Jin
VestibuloCochlear Research Center and Department of Microbiology, School of Medicine, Wonkwang University
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