Baicalein Prevents 6-Hydroxydopamine-Induced Dopaminergic Dysfunction and Lipid Peroxidation in Mice
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概要
- 論文の詳細を見る
The effects of baicalein on 6-hydroxydopamine (6-OHDA)-induced neurotoxicity were evaluated. Intracerebroventricularly (i.c.v.) injection of 6-OHDA was done to young mice. Baicalein was administered intraperitoneally 30 min before and 90 min after i.c.v. injection. Animals received further injection of bacalein daily for 3 consecutive days. Rotarod performance was assessed, tyrosine hydroxylase (TH) Western blotting was performed, and dopamine (DA) levels and peroxidation were determined. High dose of baicalein effectively improved rotarod performance and prevented the reduction of striatal DA levels and TH contents in the striatum and subtantia nigra (SN). In addition, lipid peroxidation level was decreased by baicalein at 3 and 7 days after 6-OHDA injection. These results showed that baicalein effectively prevents the 6-OHDA-induced dopaminergic dysfunction through an antioxidative action.
- 社団法人 日本薬理学会の論文
- 2005-06-20
著者
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KIM Yong
Department of Metallurgy and Materials Science, Hanyang University
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Joo Wan
Division Of Biologics Evaluation Korea Food And Drug Administration
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IM Heh-In
Department of Pharmacology, College of Medicine and Neuroscience Research Institute, Medical Researc
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NAM Eunjoo
Department of Pharmacology, College of Medicine and Neuroscience Research Institute, Medical Researc
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LEE Eun-sun
Department of Pharmacology, College of Medicine and Neuroscience Research Institute, Medical Researc
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HWANG Yu-jin
Department of Pharmacology, College of Medicine and Neuroscience Research Institute, Medical Researc
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Im Heh-in
Department Of Pharmacology College Of Medicine And Neuroscience Research Institute Medical Research
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Nam Eunjoo
Department Of Pharmacology College Of Medicine And Neuroscience Research Institute Medical Research
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Lee Eun-sun
Department Of Pharmacology College Of Medicine And Neuroscience Research Institute Medical Research
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Hwang Yu-jin
Department Of Pharmacology College Of Medicine And Neuroscience Research Institute Medical Research
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Kim Yong
Department Of Pharmacology College Of Medicine And Neuroscience Research Institute Medical Research
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Kim Yong
Department And Research Institute Of Rehabilitation Medicine Yonsei University College Of Medicine
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