Antifibrotic Effects of the Methanol Extract of Polygonum aviculare in Fibrotic Rats Insuced by Bile Duct Ligation and Scission
スポンサーリンク
概要
- 論文の詳細を見る
The antifibrotic effect of the methanol extract from Polygonum aviculare (PA), Artemisia capillaris (AC) and an aqueous solution of biphenyl dimethyl dicarboxylate (DDB) on liver fibrosis were studied. Liver fibrosis was induced by a bile duct ligation and scission (BDL/S) operation, duration of 4 weeks in rats. In BDL/S rats, the levels of aspartate transaminase (AST), alanine transaminase (ALT), alkaline phosphatase (ALP), total bilirubin in serum and hydroxyproline content in liver dramatically increased. The PA treatment in BDL/S rawts reduced the serum AST, ALT and ALP levels significantly (p<0.01). Liver hydroxyproline content in PA treated BDL/S group was also reduced to 40% that of BDL/S control group (p<0.01). The morphological characteristics of fibrotic liver, which appeared in BDL/S control group were improved in the PA treated BDL/S group. But neither AC nor DDB treatment improved any parameters in fibrotic rats induced by BDL/S. These results indicate that PA has an antifibrotic effect on fibrotic rats induced by BDL/S.
- 公益社団法人日本薬学会の論文
- 2000-02-01
著者
-
Sohn Dong
韓国
-
Sohn Dong
Department Of Pharmacy College Of Pharmacy Wonkwang University
-
Sohn Dong
Medicinal Resources Research Center College Of Pharmacy Wonkwang University
-
Sohn D
College Of Pharmacy Wonkwang University
-
NAN Ji-Xing
Medicinal Resources Research Center, College of Pharmacy Wonkwang University
-
PARK Eun-Jeon
Medicinal Resources Research Center, College of Pharmacy Wonkwang University
-
KIM Hye-Jung
Department of Family Medicine, School of Medicine Wonkwang University
-
KO Geonil
Medicinal Resources Research Center, College of Pharmacy Wonkwang University
-
Park Eun-jeon
Medicinal Resources Research Center College Of Pharmacy Wonkwang University
-
Ko Geonil
Medicinal Resources Research Center College Of Pharmacy Wonkwang University
-
Nan Ji-xing
Medicinal Resources Research Center College Of Pharmacy Wonkwang University
-
Kim Hye-jung
Department Of Family Medicine School Of Medicine Wonkwang University
-
Kim Hye-jung
Department Of Bioscience And Biotechnology Konkuk University
-
Shin Dong-won
Department Of Oriental Medicine Resources College Of Bio Industry Science Sunchon National Universit
-
Shin Dong-young
Department Of Development In Plant Resources College Of Bio Industry Science Sunchon National Univer
関連論文
- 5-Hydroxytryptophan Acts on the Mitogen-Activated Protein Kinase Extracellular-Signal Regulated Protein Kinase Pathway to Modulate Cyclooxygenase-2 and Inducible Nitric Oxide Synthase Expression in RAW 264.7 Cells(Biochemistry)
- The Anti-inflammatory and Anti-nociceptive Effects of Ethyl Acetate Fraction of Cynanchi Paniculati Radix(Pharmacognosy)
- Antifibrotic Effects of the Methanol Extract of Polygonum aviculare in Fibrotic Rats Insuced by Bile Duct Ligation and Scission
- Antifibrotic Effects of a Polysaccharide Extracted from Ganoderma lucidum, Glycyrrhizin, and Pentoxifylline in Rats with Cirrhosis Induced by Biliary Obstruction
- Ginsenoside Compound K Production from Ginseng Root Extract by a Thermostable β-Glycosidase from Sulfolobus solfataricus
- Antimalarial Activity of Lavandulyl Flavanones Isolated from the Roots of Sophora flavescens (Pharmacognosy)
- Low-Temperature Crystallization of Amorphous Si Films by Metal Adsorption and Diffusion
- New Crystallization Process of LPCVD a-Si Films below 530℃ Using Metal Adsorption Method
- Ginsenoside Compound K Production from Ginseng Root Extract by a Thermostable β-Glycosidase from Sulfolobus solfataricus
- Antibacterial and synergistic effects of Smallanthus sonchifolius leaf extracts against methicillin-resistant Staphylococcus aureus under light intensity
- The mechanism of action of sanguinarine against methicillin-resistant Staphylococcus aureus
- Synergistic effect of tetrandrine and ethidium bromide against methicillin-resistant Staphylococcus aureus (MRSA)