The Anti-inflammatory and Anti-nociceptive Effects of Ethyl Acetate Fraction of Cynanchi Paniculati Radix(Pharmacognosy)
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概要
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The anti-inflammatory and anti-nociceptive effects and sedative activities of the ethyl acetate fraction of Cy-nanchum paniculatum (EACP) were evaluated in mice and rats by acetic acid-induced vascular permeability, arachidonic acid-induced paw edema, cotton pellet-induced granuloma formation, formalin-induced licking time, acetic acid-induced writhing response, and pentobarbital-induced sleeping time. EACP at a dose of 40mg/kg significantly exhibited anti-inflammatory activities on acetic acid-induced vascular permeability, arachidonic acid-induced paw edema, and the late phase of formalin-induced licking time. Moreover, it showed anti-nociceptive effects on acetic acid-induced writhing responses and significant sedative effects on pentobarbital-induced sleeping time. The results demonstrated that the anti-nociceptive effects are apparently related to the sedative effects of EACP. These results support the use of Cynanchum paniculatum in relieving inflammatory pain.
- 公益社団法人日本薬学会の論文
- 2006-05-01
著者
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Sohn Dong
韓国
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Sohn Dong
Department Of Pharmacy College Of Pharmacy Wonkwang University
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Sohn Dong
Medicinal Resources Research Center College Of Pharmacy Wonkwang University
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Kwon Dong-yeul
Department Of Oriental Pharmacy College Of Pharmacy Wonkwang University Wonkwang Oriental Medicines
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Park Hyun
Department of Systems Innovation, Graduate School of Engineering, The University of Tokyo
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Choi Jung-hyun
Department Of Oriental Pharmacy College Of Pharmacy Wonkwang University Wonkwang Oriental Medicines
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Sohn D
College Of Pharmacy Wonkwang University
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Sohn Dong
Department Of Materials Science And Engineering Korea Advanced Institute Of Science And Technology
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Kim Youn-chul
Department Of Pharmacy College Of Pharmacy Wonkwang University
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Choi Hyuk
Department Of Oriental Pharmacy College Of Pharmacy Wonkwang University
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Park Pil
Department Of Oriental Pharmacy College Of Pharmacy Wonkwang University
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Cho Sun
Department of Microbiology, College of Natural Sciences, Pusan National University
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LEE John
College of Veterinary Medicine, Chonbuk National University
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Cho Sun
Department Of Oriental Pharmacy College Of Pharmacy Wonkwang University
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KANG Ok-Hwa
Department of Oriental Pharmacy, College of Pharmacy, Wonkwang University, Wonkwang Oriental Medicin
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JUNG Byung-Ha
Department of Oriental Pharmacy, College of Pharmacy, Wonkwang University
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Kang Ok-hwa
Department Of Oriental Pharmacy College Of Pharmacy Wonkwang University Wonkwang Oriental Medicines
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Jung Byung-ha
Department Of Oriental Pharmacy College Of Pharmacy Wonkwang University
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Lee John
College Of Veterinary Medicine And Bio-safety Research Institute Jeonbuk National University
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Cho Sun
Department Of Microbiology College Of Natural Sciences Pusan National University
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Choi Hyuk
Department Of Electronic Materials Engineering Kwangwoon University
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Choi Jung-hyun
Department Of Biotechnology Dongguk University
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Park Pil
Department Of Forest Sciences Seoul National University
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Park Hyun
Department Of Computer Science Korea Advanced Institute Of Science & Technology
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Choi Jang-gi
Department Of Oriental Pharmacy College Of Pharmacy Wonkwang Oriental Medicines Research Institute W
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Shin Dong-won
Department Of Oriental Medicine Resources College Of Bio Industry Science Sunchon National Universit
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Kwon Dong-yeul
Department Of Oriental Pharmacy College Of Pharmacy Wonkwang Oriental Medicines Research Institute W
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Shin Dong-young
Department Of Development In Plant Resources College Of Bio Industry Science Sunchon National Univer
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Kwon Dong-yeul
Wonkwang University College Of Pharmacy And Wonkwang-oriental Medicines Research Institute
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Kang Ok-hwa
Wonkwang University College Of Pharmacy And Wonkwang-oriental Medicines Research Institute
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Park Pil
Department Of Forest Sciences And Research Institute For Agriculture And Life Sciences Seoul Nationa
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Choi Jang-gi
Wonkwang University College Of Pharmacy And Wonkwang-oriental Medicines Research Institute
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Park Hyun
Department Of Computer Science Chungnam National University
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Park Hyun
Department Of Chemical & Biomolecular Engineering Korea Advanced Institute Of Science & Tech
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Cho Sun
Department Of Laboratory Medicine School Of Medicine Kyung Hee University
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Park Hyun
Department Of Ceramic Engineering Chonnam National University
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Park Hyun
Department of Biotechnology, Yeungnam University
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