Semi-vioxanthin Isolated from Marine-Derived Fungus Regulates Tumor Necrosis Factor-α, Cluster of Differentiation (CD) 80, CD86, and Major Histocompatibility Complex Class II Expression in RAW264.7 Cells via Nuclear Factor-κB and Mitogen-Activated Protein
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概要
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Semi-vioxanthin isolated from marine-derived fungus was assessed for immunoregulatory activity in mouse RAW264.7 macrophages. In the present study, the facilitative effects of semi-vioxanthin on tumor necrosis factor-α (TNF-α) and its mRNA expression and on expression of the co-stimulatory molecules, cluster of differentiation (CD) 80, CD86 and major histocompatibility complex class II (MHC II), as well as the molecular mechanism underlying the immunologic enhancement properties of semi-vioxanthin were studied. Our results clearly indicated that semi-vioxanthin treatment resulted in the degradation of IκBα, which led to the activation and nuclear translocation of the p65 subunit of nuclear factor-κB (NF-κB), as determined by immunoblotting, immunofluorescence and electrophoretic mobility shift assays (EMSA). Moreover, TNF-α production was prevented by NF-κB and mitogen-activated protein kinase (MAPK) inhibitors. Inhibition of NF-κB and extracellular signal regulated kinases (ERK1/2) activity by specific inhibitors blunted the effect of semi-vioxanthin on the up-regulation of CD80, CD86 and MHCII expression, but neither p38 MAPK nor c-Jun N-terminal kinase (JNK) inhibitor had this effect. Thus, we demonstrate that semi-vioxanthin regulates TNF-α production through NF-κB and MAPK signaling pathways. Activation of NF-κB and ERK1/2 were necessary for CD80, CD86 and MHCII expression induced by semi-vioxanthin. These data suggest that semi-vioxanthin has immunoregulatory effects.
- 公益社団法人日本薬学会の論文
- 2008-12-01
著者
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Lee Joo-Young
Department of Ergonomics, Faculty of Design, Kyushu University
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SHIN Hye-Young
Department of Pharmacology, College of Oriental Medicine. Kyung Hee University
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Park Hyun
韓国
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Park Hyun
Department of Systems Innovation, Graduate School of Engineering, The University of Tokyo
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YANG Xin-Ying
Department of Infection Biology, Zoonosis Research Center, Wonkwang University School of Medicine
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CAI Sheng-Xin
Key Laboratory of Marine Drugs, Chinese Ministry of Education, Institute of Marine Drugs and Food, O
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ZHANG Wen-Ji
Department of Infection Biology, Zoonosis Research Center, Wonkwang University School of Medicine
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TANG Xue-Lian
Department of Infection Biology, Zoonosis Research Center, Wonkwang University School of Medicine
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Gu Qian-Qun
Key Laboratory of Marine Drugs, Chinese Ministry of Education, Institute of Marine Drugs and Food, O
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Lee Joo-young
Department Of Life Science Gwangju Institute Of Science And Technology
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Lee Joo-young
Department Of Clothing & Textile College Of Human Ecology Seoul National University
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Zhang Wen-ji
Department Of Infection Biology Zoonosis Research Center Wonkwang University School Of Medicine
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Gu Qian-qun
Key Laboratory Of Marine Drugs Chinese Ministry Of Education Institute Of Marine Drugs And Food Ocea
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Cai Sheng-xin
Key Laboratory Of Marine Drugs Chinese Ministry Of Education Institute Of Marine Drugs And Food Ocea
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Shin Hye-young
Department Of Infection Biology Zoonosis Research Center Wonkwang University School Of Medicine
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Park Hyun
Department Of Computer Science Korea Advanced Institute Of Science & Technology
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Park Hyun
Department Of Computer Science Chungnam National University
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Park Hyun
Department Of Chemical & Biomolecular Engineering Korea Advanced Institute Of Science & Tech
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Park Hyun
Department Of Ceramic Engineering Chonnam National University
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Gu Qian-qun
Key Laboratory Of Marine Drugs Chinese Ministry Of Education ; School Of Medicine And Pharmacy Ocean University Of China
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Park Hyun
Department of Biotechnology, Yeungnam University
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