Anti-toxoplasmosis Effects of Oleuropein Isolated from Fraxinus rhychophylla(Pharmacognosy)
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概要
- 論文の詳細を見る
Toxoplasmosis is a parasitic disease caused by Toxoplasma gondii, with very few therapeutic treatment options. Typically, the choices for treatment are pyrimethamine and sulfadiazine, however their utility is limited because of drug toxicity and serious side effects. For these reasons, new drugs with lower toxicity are urgently needed. In this study, the compound oleuropein isolated from Fraxinus rhynchophylla showed anti-T. gondii effects in vitro and in vivo. In Madin-Darby bovine kidney cells, the selectivity of oleuropein was 8.9, which was higher than sulfadiazine and pyrimethamine (3.8 and 2.5, respectively). In infected mice, the inhibition ratio of T. gondii in the peritoneal cavity was 55.4% compared to the negative control group after treatment with 300mg/kg oleuropein. In addition, inhibitory effects on granuloma, apoptosis, necrosis and cyst-formation were shown in sections of spleen and liver. Oleuropein is therefore a potentially useful anti-T. gondii candidate for clinical application.
- 公益社団法人日本薬学会の論文
- 2008-12-01
著者
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Kim Youn-chul
College Of Pharmacy Medicinal Resources Research Center Wonkwang University
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Jin Chun-mei
Department Of Infection Biology Zoonosis Research Center Wonkwang University School Of Medicine
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Jiang Jing-hua
Department Of Infection Biology Zoonosis Research Center Wonkwang University School Of Medicine
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Park Won-cheol
Department Of Surgery Wonkwang University School Of Medicine
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Park Hyun
Department Of Computer Science Korea Advanced Institute Of Science & Technology
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KIM Hun-Soo
Department of Pathology, Wonkwang University School of Medicine
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Kim Hun-soo
Department Of Pathology Wonkwang University School Of Medicine
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Park Hyun
Department Of Computer Science Chungnam National University
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Park Hyun
Department Of Infection Biology Zoonosis Research Center Wonkwang University School Of Medicine
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Park Hyun
Department Of Chemical & Biomolecular Engineering Korea Advanced Institute Of Science & Tech
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Park Hyun
Department Of Ceramic Engineering Chonnam National University
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Park Hyun
Department of Biotechnology, Yeungnam University
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