Heme Oxygenase-1 Inducing Constituent of Prunella vulgaris in HepG2 Cells(Pharmacognosy)
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概要
- 論文の詳細を見る
Inducible heme oxygenase (HO)-1 is known to play a major role in the pathogenesis of several diseases, and it protects cells against oxidant-mediated injury. The bioassay-guided fractionation of the EtOH extract of the flowered fruit-spike of Prunella vulgaris L. (Labiatae) yielded two ursane-type triterpenes, 3β,23-dihydroxyurs-12-en-28-oic acid (23-hydroxyursolic acid) (1) and 3β-hydroxyurs-12-en-28-oic acid (ursolic acid) (2). Western blotting demonstrated that treatment with compound 1 increased the expression of HO-1 in a dose-dependent manner in human liver-derived HepG2 cells. Investigation of structure-related HO-1 inducing activity suggested that the hydroxyl group at the C-23 position in the ursane skeleton is important for this activity.
- 社団法人日本薬学会の論文
- 2008-03-01
著者
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Kim Youn-chul
College Of Pharmacy Wonkwang University
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Kim Youn-chul
中華人民共和国
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Kim Youn-chul
Coll. Of Pharmacy Wonkwang Univ.
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AN Ren-Bo
College of Pharmacy, Chungnam National University
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Jeong Gil-saeng
韓国
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Jeong Gil-saeng
Korea Research Institute Of Bioscience And Biotechnology
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PAE Hyun-Ock
Department of Microbiology and Immunology, Wonkwang University School of Medicine
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CHUNG Hun-Taeg
Department of Microbiology and Immunology, Wonkwang University School of Medicine
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JEONG Gil-Saeng
X-Ray Microscopy Research Center, Wonkwang University
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OH Gi-Su
Department of Microbiology and Immunology, Wonkwang University School of Medicine
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Pae Hyun-ock
韓国
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Pae Hyun-ock
Department Of Microbiology And Immunology Wonkwang University School Of Medicine
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Pae Hyun-ock
Medical Resources Research Center Of Wonkwang University
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Oh Gi-su
Department Of Microbiology And Immunology Wonkwang University School Of Medicine
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Oh Gi-su
韓国
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Oh Gi-su
Medical Resources Research Center Of Wonkwang University
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Chung Hun-taeg
Department Of Microbiology And Immunology Wonkwang University School Of Medicine
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Chung Hun-taeg
Department Of Immunology Medical Resources Research Institute Wonkwang University
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Chung Hun-taeg
Medical Resources Research Center Of Wonkwang University
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Chung Hun-taeg
Genomic Research Center For Immune Disorders Wonkwang University School Of Medicine
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An Ren-bo
韓国
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An Ren-bo
Key Lab. Of Organism Functional Factors Of The Changbai Mountain Coll. Of Pharmacy Yanbian Univ.
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An Ren-bo
Laboratory Of Immunomodulator Korea Research Institute Of Bioscience And Biotechnology
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An Ren
韓国
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An Ren
Laboratory Of Immunomodulator Korea Research Institute Of Bioscience And Biotechnology
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An Ren-bo
College Of Pharmacy Chungnam National University
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Kim Youn-chul
Coll. Of Pharmacy Wonkwang Univ. Kor
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Kim Youn-chul
College Of Pharmacy Medicinal Resources Research Center Wonkwang University
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Jeong Gil-saeng
College Of Pharmacy Keimyung University
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