Lignans and Coumarins from the Roots of Anthriscus sylvestris and Their Increase of Caspase-3 Activity in HL-60 Cells(Pharmacognosy)

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概要

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• A new lignan, sylvestrin (1), was isolated from the MeOH-soluble fraction of the roots of Anthriscus sylvestris HOFFM. (Umbelliferae), along with six lignans (2-7), three coumarins (8-10), and a polyacetylene (11). The structure of sylvestrin was determined to be 2-(3',4',5'-trimethoxybenzylidene)-3-(3",4"-methylendioxybenzyl)-γ-butyrolactone (1) by spectroscopic means, including 2D-NMR. The eleven compounds were assessed for their abilities to activate a caspase-3 in human promyeloid leukemic HL-60 cells. The intracellular caspase-3 activity of (-)-deoxypodophyllotoxin (3), angeloyl podophyllotoxin (5), deoxypicropodophyllin (6), picropodophyllotoxin (7), and falcarindiol (11) increased approximately 4.6, 3.6, 3.7, 3.9, and 3.9-fold, at 0.001, 1, 1, 1, and 20μM, respectively, over that of the untreated control. In addition, compounds 3, 5, 6, and 7 showed apoptosis-inducing activities that were measured by DNA fragmentation in HL-60 cells.

• 社団法人日本薬学会の論文
• 2007-07-01

著者

• Kim Youn-chul

  College Of Pharmacy Wonkwang University

• 金城 順英

  熊本大学 医薬

• Jeong Gil-saeng

  韓国

• Jeong Gil-saeng

  Korea Research Institute Of Bioscience And Biotechnology

• Kinjo Junei

  東海大学 農学部

• Kinjo Junei

  Department Of Pharmacognosy Faculty Of Pharmaceutical Sciences Fukuoka University

• Kinjo Junei

  福岡大学 薬学部

• Kinjo Junei

  Faculty Of Pharmaceutical Sciences Kumamoto University

• Kinjo Junei

  熊本大学 薬

• Lee Hyeong-kyu

  韓国

• Lee Hyeong-kyu

  Korea Research Institute Of Bioscience And Biotechnology

• Min Byung-sun

  Coll. Of Pharmacy Catholic Univ. Of Daegu

• Min B‐s

  College Of Pharmacy Catholic University Of Daegu

• Min Byung

  Institute Of Natural Medicine Toyama Medical And Pharmaceutical University

• 金城 順英

  熊本大学 薬

• Jung K

  Laboratory Of Immunomodulator Korea Research Institute Of Bioscience And Biotechnology

• Min Byung-sun

  College Of Pharmacy Catholic University Of Daegu

• Kim Youn-chul

  College Of Pharmacy Medicinal Resources Research Center Wonkwang University

• Kim J‐h

  Korea Res. Inst. Of Bioscience And Biotechnology Daejeon Kor

• Ahn K

  Korea Research Institute Of Bioscience And Biotechnology

• KWON Ok-Kyoung

  Korea Research Institute of Bioscience and Biotechnology

• PARK Bo-Young

  Korea Research Institute of Bioscience and Biotechnology

• OH Sei-Ryang

  Korea Research Institute of Bioscience and Biotechnology

• AHN Kyung-Seop

  Korea Research Institute of Bioscience and Biotechnology

• CHANG Min-Jung

  College of Pharmacy, Catholic University of Daegu

• OH Won

  College of Pharmacy, Chosun University

• KIM Jin-Cheol

  Korea Research Institute of Chemical Technology

• Ahn K‐s

  Cancer Preventive Material Development Research Center College Of Oriental Medicine Kyunghee Univers

• Ahn Kwang

  Cancer Preventive Material Dev. Res. Center Coll. Of Oriental Medicine Kyunghee Univ.

• Kinjo J

  Faculty Of Pharmaceutical Sciences Fukuoka University

• Kim J-h

  Faculty Of Pharmaceutical Sciences Fukuoka University

• Min Byung-sun

  Laboratory Of Immunomodulator Korea Research Institute Of Bioscience And Biotechnology

• Jung K

  Korea Res. Inst. Biosci. And Biotechnol. Taejon Kor

• Lee Hyeong-kyu

  Korea Res. Inst. Of Bioscience And Biotechnology

• Lee Hyeong-kyu

  Natural Product Biosynthesis Research Unit Korea Research Institute Of Bioscience & Biotechnolog

• Oh Won

  College Of Pharmacy Chosun University

• Min Byung

  Laboratory Of Immunomodulator Korea Research Institute Of Bioscience And Biotechnology

• Oh Sei-ryang

  Korea Research Institute Of Bioscience And Biotechnology:college Of Pharmacy Wonkwang University

• Ahn K

  Seoul National Univ. Seoul Kor

• Kinjyo Junei

  Faculty Of Pharmaceutical Sciences Kumamoto University

• Chang Min-jung

  College Of Pharmacy Catholic University Of Daegu

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