Hepatoprotective Compounds of the Roots of Cudrania tricuspidata on Tacrine-Induced Cytotoxicity in Hep G2 Cells(Pharmacognosy)
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概要
- 論文の詳細を見る
The bioassay-guided fractionation of the MeOH extract of the root barks of Cudrania tricuspidata furnished three hepatoprotective compounds, gerontoxanthone A (2), cudraflavone B (4), gericudranin E (5), together with four prenylated xanthones, cudraxanthone B (3), isocudraxanthone K (6), cudraxanthone C (7), cudraxanthone H (8), and a prenylated flavanone, euchrestaflavanone C (1). Compounds 4 and 5 showed significant hepatoprotective effects with the EC_<50> values of 37.39±0.4 and 39.87±0.7μM, respectively, and compound 2 showed moderate hepatoprotective effect with an EC_<50> value of 125.9±1.5μM, against tacrine-induced cytotoxicity in Hep G2 cells. Silybin as positive control showed an EC_<50> value of 84.76±0.5μM. Isocudraxanthone K (6) is a new compound.
- 公益社団法人日本薬学会の論文
- 2006-04-01
著者
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Kim Youn-chul
College Of Pharmacy Wonkwang University
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AN Ren-Bo
College of Pharmacy, Chungnam National University
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An Ren-bo
College Of Pharmacy Wonkwang University:college Of Pharmacy Yanbian University
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An Ren-bo
College Of Pharmacy Chungnam National University
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SOHN Dong-Hwan
College of Pharmacy and Medicinal Resources Research Institute, Wonkwang University
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Sohn Dong-hwan
College Of Pharmacy Wonkwang University
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Sohn Dong-hwan
College Of Pharmacy And Institute Of Pharmaceutical Research & Development Wonkwang University
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Kim Youn-chul
College Of Pharmacy Medicinal Resources Research Center Wonkwang University
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