cis-Hinokiresinol, a Norlignan from Anemarrhena asphodeloides, Inhibits Angiogenic Response in Vitro and in Vivo (Pharmacognosy)

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概要

• 論文の詳細を見る

• cis-Hinokiresinol (CHR) is a norlignan constituent from Anemarrhena asphodeloides BUNGE (Liliaceae), which shows hyaluronidase inhibitory activity. In the present studies, we have demonstrated that CHR selectively inhibited endothelial cell proliferation compared with cancer cells, and especially basic fibroblast growth factor (bFGF) or vascular endothelial growth factor (VEGF)-induced endothelial cell proliferation. Furthermore, endothelial cell migration and tube formation, two important steps in the angiogenic process, were also inhibited by CHR. Moreover, CHR reduced the vessel growth induced by VEGF in the mouse corneal neovascularization model. These results suggest that CHR may prove useful for the development of a novel angiogenesis inhibitor.

• 公益社団法人日本薬学会の論文
• 2003-12-01

著者

• Ono Mayumi

  Department Of Pharmaceutical Oncology Graduate School Of Pharmaceutical Sciences Kyushu University

• Ono M

  Departments Of Biochemistry Kyushu University School Of Medicine

• KUWANO Michihiko

  Research Center of Innovative Cancer Therapy, Kurume University School of Medicine

• Ono Mayumi

  Graduate School Of Medical Sciences Kyushu University

• MIYAMOTO Tomofumi

  Graduate School of Pharmaceutical Sciences, Kyushu University

• HIGUCHI Ryuichi

  Graduate School of Pharmaceutical Sciences, Kyushu University

• Kim Youn-chul

  College Of Pharmacy Wonkwang University

• Jeong Sei-joon

  Graduate School Of Pharmaceutical Sciences Kyushu University

• Jeong Sei-joon

  九州大学 薬研究院

• Kuwano Michihiko

  九州大学 医学研究院形態機能病理学

• Kuwano M

  Research Center For Innovate Cancer Therapy Kurume University

• Kuwano M

  Departments Of Biochemistry Kyushu University School Of Medicine

• Ono Mayumi

  Graduate School Of Arts And Sciences University Of Tokyo

• Kim Youn-chul

  College Of Pharmacy Medicinal Resources Research Center Wonkwang University

• Ono M

  Analytical Laboratory Self-medication Laboratories Taisho Pharmaceutical Co. Ltd.

• Miyamoto Tomofumi

  Graduate School Of Pharmaceutical Sciences Kyushu Univ.

• KUWANO Michihiko

  Graduate School of Medical Sciences, Kyushu University

• Kuwano M

  Innovative Anticancer Diagnosis And Therapeutics Innovation Center For Medical Redox Navigation Kyus

• Kuwano Michihiko

  Research Center For Innovative Cancer Therapy Kurume University

• Kuwano Michihiko

  Graduate School Of Medical Sciences Kyushu University

• Higuchi Ryuichi

  Graduate School Of Pharmaceutical Sciences Kyushu Univ.

• Ono Masaki

  Analytical Laboratory Self-medication Laboratories Taisho Pharmaceutical Co. Ltd.

• Ono M

  Faculty Of Pharmaceutical Sciences Tokushima Bunri University

• Kim Y‐c

  College Of Pharmacy Wonkwang University

• Maruta Tomoki

  Graduate School Of Pharmaceutical Sciences Kyushu University

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