Cytoprotective Constituents of the Heartwood of Caesalpinia sappan on Glutamate-Induced Oxidative Damage in HT22 Cells
スポンサーリンク
概要
- 論文の詳細を見る
The bioassay-guided fractionation of a MeOH extract of the heartwood of Caesalpinia sappan L. provided two neuroprotective compounds, sappanchalcone (2) and 4-O-methylepisappanol (3), together with a methoxychalcone, isoliquiritigenin 2′-methyl ether (1), and three aromatic compounds, 4-O-methylsappanol (4), caesalpine J (5), pluchoic acid (6). At concentrations of 20—40 μm, compound 2 showed significant cytoprotective effects against glutamate-induced oxidative stress through the induction of heme oxygenase (HO)-1 in HT22-immortalized hippocampal cells. Compound 3 also showed moderate neuroprotective effect at 40 μm, but compounds 1, 4—6 did not show any protective effects against glutamate-induced cytotoxicity in HT22 cells.
- 日本薬学会の論文
著者
-
Kim Youn-chul
College Of Pharmacy Wonkwang University
-
Lee Dong-sung
韓国
-
Jeong Gil-saeng
韓国
-
Jeong Gil-Saeng
Institute of Radiological Imaging Science, Wonkwang University
-
Lee Dong-Sung
College of Pharmacy, Wonkwang University
-
Kwon Tae-Oh
College of Life Science and Natural Resources, Wonkwang University
-
Lee Hye-Suk
Drug Metabolism and Bioanalysis Laboratory, College of Pharmacy, Wonkwang University
-
An Ren-Bo
Key Laboratory of Organism Functional Factors of the Changbai Mountain, College of Pharmacy, Yanbian
-
An Ren-bo
Key Lab. Of Organism Functional Factors Of The Changbai Mountain Coll. Of Pharmacy Yanbian Univ.
-
Kim Youn-chul
College Of Pharmacy Medicinal Resources Research Center Wonkwang University
-
Jeong Gil-saeng
College Of Pharmacy Keimyung University
関連論文
- Inhibitory Effects of Nardostachin on Nitric Oxide, Prostaglandin E_2, and Tumor Necrosis Factor-α Production in Lipopolysaccharid Activated Macrophages(Biochemistry/Molecular Biology)
- Cytoprotective Constituents of the Heartwood of Caesalpinia sappan on Glutamate-Induced Oxidative Damage in HT22 Cells
- Flavonoids from the Heartwood of Dalbergia odorifera and Their Protective Effect on Glutamate-Induced Oxidative Injury in HT22 Cells
- Lavandulyl Flavanones from Sophora flavescens Protect Mouse Hippocampal Cells against Glutamate-Induced Neurotoxicity via the Induction of Heme Oxygenase-1(Pharmacognosy)
- Heme Oxygenase-1 Inducing Constituent of Prunella vulgaris in HepG2 Cells(Pharmacognosy)
- In Vitro Inducible Nitric Oxide Synthesis Inhibitors from Alismatis Rhizoma
- Butein from Rhus verniciflua Protects Pancreatic β Cells against Cytokine-Induced Toxicity Mediated by Inhibition of Nitric Oxide Formation
- Lignans and Coumarins from the Roots of Anthriscus sylvestris and Their Increase of Caspase-3 Activity in HL-60 Cells(Pharmacognosy)
- Iridoid Esters from Patrinia saniculaefolia
- Magnolia officinalis Reverses Alcoholic Fatty Liver by Inhibiting the Maturation of Sterol Regulatory Element-Binding Protein-1c
- A New Naphthopyrone from the Root of Pleuropterus ciliinervis
- Antioxidant Activity of Two Phloroglucinol Derivatives from Dryopteris crassirhizoma(Pharmacognosy)
- cis-Hinokiresinol, a Norlignan from Anemarrhena asphodeloides, Inhibits Angiogenic Response in Vitro and in Vivo (Pharmacognosy)
- Effect of Astilbe koreana on Ultraviolet B (UVB)-Induced Inflammatory Response in Human Keratinocytes(Pharmacognosy)
- BUTEIN (3,4,2',4'-TETRAHYDROXYCHALCONE) INHIBITS DEPOSITION OF EXTRACE LLULAR MATRIX IN EXPERIMENTAL LIVER FIBROSIS IN RATS
- Hepatoprotective Compounds of the Roots of Cudrania tricuspidata on Tacrine-Induced Cytotoxicity in Hep G2 Cells(Pharmacognosy)
- Phenolic Constituents of Galla Rhois with Hepatoprotective Effects on Tacrine- and Nitrofurantoin-Induced Cytotoxicity in Hep G2 Cells(Pharmacognosy)
- Asperlin from the marine-derived fungus Aspergillus sp. SF-5044 exerts anti-inflammatory effects through heme oxygenase-1 expression in murine macrophages
- Asperlin From the Marine-Derived Fungus Aspergillus sp. SF-5044 Exerts Anti-inflammatory Effects Through Heme Oxygenase-1 Expression in Murine Macrophages
- Sauchinone Suppresses Pro-inflammatory Mediators by Inducing Heme Oxygenase-1 in RAW264.7 Macrophages
- Anti-toxoplasmosis Effects of Oleuropein Isolated from Fraxinus rhychophylla(Pharmacognosy)
- Nitric Oxide Modulates Osteoblastic Differentiation with Heme Oxygenase-1 via the Mitogen Activated Protein Kinase and Nuclear Factor-kappaB Pathways in Human Periodontal Ligament Cells
- Asperlin From the Marine-Derived Fungus Aspergillus sp. SF-5044 Exerts Anti-inflammatory Effects Through Heme Oxygenase-1 Expression in Murine Macrophages
- 6,4'-dihydroxy-7-methoxyflavanone Inhibits Osteoclast Differentiation and Function
- Studies on Lymphangiogenesis Inhibitors from Korean and Japanese Crude Drugs