Lavandulyl Flavanones from Sophora flavescens Protect Mouse Hippocampal Cells against Glutamate-Induced Neurotoxicity via the Induction of Heme Oxygenase-1(Pharmacognosy)
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概要
- 論文の詳細を見る
Lavandulyl flavanones of Sophora flavescens roots are anti-malarial, anti-inflammatory, and cytotoxic. Here, we examined whether four lavandulyl flavanones, (2S)-2'-methoxykurarinone (1), sophoraflavanone G (2), leachianone A (3), and (-) -kurarinone (4), isolated from S. flavescens could protect HT22 immortalized hippocampal cells against glutamate-induced oxidative stress. Compounds 1 and 2 induced the expression of heme oxygenase (HO)-1 and increased HO activity dose- and time-dependently. These two compounds also suppressed glutamate-induced reactive oxygen species generation in HT22 cells, whereas compounds 3 and 4 were not protective. These two lavandulyl flavanones (compounds 1, 2) may protect against glutamate-induced neurotoxicity via HO-1 induction.
- 社団法人日本薬学会の論文
- 2008-10-01
著者
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Kim Youn-chul
College Of Pharmacy Wonkwang University
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Kim Youn-chul
中華人民共和国
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Kim Youn-chul
Coll. Of Pharmacy Wonkwang Univ.
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AN Ren-Bo
College of Pharmacy, Chungnam National University
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Lee Dong-sung
韓国
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Jeong Gil-saeng
韓国
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Jeong Gil-saeng
Korea Research Institute Of Bioscience And Biotechnology
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Jeong Gil-Saeng
Institute of Radiological Imaging Science, Wonkwang University
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Lee Dong-Sung
College of Pharmacy, Wonkwang University
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LI Bin
College of Pharmacy, Wonkwang University
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BYUN Erisa
College of Pharmacy, Wonkwang University
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PAE Hyun-Ock
Department of Microbiology and Immunology, Wonkwang University School of Medicine
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CHUNG Hun-Taeg
Department of Microbiology and Immunology, Wonkwang University School of Medicine
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YOUN Kwon-Ha
Institute for Radiological Imaging Science, Wonkwang University
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Byun Erisa
College Of Pharmacy Wonkwang University
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Youn Kwon-ha
Institute For Radiological Imaging Science Wonkwang University
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Pae Hyun-ock
韓国
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Pae Hyun-ock
Department Of Microbiology And Immunology Wonkwang University School Of Medicine
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Pae Hyun-ock
Medical Resources Research Center Of Wonkwang University
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Chung Hun-taeg
Department Of Microbiology And Immunology Wonkwang University School Of Medicine
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Chung Hun-taeg
Department Of Immunology Medical Resources Research Institute Wonkwang University
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Chung Hun-taeg
Medical Resources Research Center Of Wonkwang University
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Chung Hun-taeg
Genomic Research Center For Immune Disorders Wonkwang University School Of Medicine
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An Ren-bo
韓国
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An Ren-bo
Key Lab. Of Organism Functional Factors Of The Changbai Mountain Coll. Of Pharmacy Yanbian Univ.
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An Ren-bo
Laboratory Of Immunomodulator Korea Research Institute Of Bioscience And Biotechnology
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An Ren
韓国
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An Ren
Laboratory Of Immunomodulator Korea Research Institute Of Bioscience And Biotechnology
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An Ren-bo
College Of Pharmacy Chungnam National University
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Kim Youn-chul
Coll. Of Pharmacy Wonkwang Univ. Kor
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Kim Youn-chul
College Of Pharmacy Medicinal Resources Research Center Wonkwang University
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Li Bin
College Of Pharmacy Wonkwang University
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Li Bin
Jiangxi University Of Traditional Chinese Medicine:beijing University Of Traditional Chinese Medicin
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Lee Dong-sung
Standardized Material Bank For New Botanical Drugs College Of Pharmacy Wonkwang University
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Jeong Gil-saeng
College Of Pharmacy Keimyung University
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