Differentiation-Inducing Effects of Verticinone, an Isosteroidal Alkaloid Isolated from the Bulbus of Fritillaria ussuriensis, on Human Promyelocytic Leukemia HL-60 Cells
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概要
- 論文の詳細を見る
The inducer of differentiation of human promyelocytic leukemia HL-60 cells is commonly accepted to have potential therapeutic importance. Verticinone, one of the major isosteroidal alkaloids from the bulbus of Fritillaria ussuriensis, was found to inhibit the growth of HL-60 cells by inducing these cells to differentiate toward granulocytes. Importantly, the combination of verticinone with all-trans retinoic acid (ATRA), a well-known inducer of HL-60 cells into granulocytic lineages, was more effective than either alone, suggesting its therapeutic use in minimizing the effective dose of ATRA.
- 社団法人日本薬学会の論文
- 2002-11-01
著者
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OH Gi-Su
Department of Microbiology and Immunology, Wonkwang University School of Medicine
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Pae Hyun-ock
韓国
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Pae Hyun-ock
Department Of Microbiology And Immunology Wonkwang University School Of Medicine
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Pae Hyun-ock
Medicinal Resources Research Institute Department Of Microbiology & Immunology Wonkwang Universi
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Pae Hyun-ock
Medical Resources Research Center Of Wonkwang University
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Oh Gi-su
Department Of Microbiology And Immunology Wonkwang University School Of Medicine
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Oh Gi-su
韓国
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Oh Gi-su
Medical Resources Research Center Of Wonkwang University
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Chung Hun-taeg
Department Of Microbiology And Immunology Wonkwang University School Of Medicine
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Chung Hun-taeg
Medicinal Resources Research Institute Department Of Microbiology & Immunology Wonkwang Universi
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Chung Hun-taeg
Medical Resources Research Center Of Wonkwang University
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Chung Hun-taeg
Genomic Research Center For Immune Disorders Wonkwang University School Of Medicine
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OH Hyuncheol
Professional Graduate School of Oriental Medicine, Wonkwang University
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CHOI Byung-Min
Medicinal Resources Research Center of Wonkwang University
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PAIK Sang-Gi
Department of Biology, College of Natural Science, Chungnam National University
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JEONG Sejin
Medicinal Resources Research Center of Wonkwang University
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HWANG Kee-Myoung
Department of Microbiology and Immunology, Wonkwang University School of Medicine
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YUN Young-Gab
Medicinal Resources Research Center of Wonkwang University
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Choi Byung-min
Medicinal Resources Research Center Of Wonkwang University:department Of Microbiology And Immunology
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Choi Byung-min
韓国
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Choi Byung-min
Medical Resources Research Center Of Wonkwang University
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Oh Hyuncheol
Professional Graduate School Of Oriental Medicine Wonkwang University
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Hwang Kee-myoung
Department Of Microbiology And Immunology Wonkwang University School Of Medicine
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Jeong Sejin
Medicinal Resources Research Center Of Wonkwang University:department Of Microbiology And Immunology
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Paik Sang-gi
Department Of Biology College Of Natural Science Chungnam National University
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Paik Sang-gi
Department Of Biology Chung Nam National University
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Yun Y‐g
Wonkwang Univ. Chunbuk Kor
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