Phenolic Constituents of Galla Rhois with Hepatoprotective Effects on Tacrine- and Nitrofurantoin-Induced Cytotoxicity in Hep G2 Cells(Pharmacognosy)
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概要
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The bioassay-guided fractionation of the MeOH extract of Galla Rhois furnished two hepatoprotective compounds, an equilibrium mixture of 3-galloyl-gallic acid and 4-galloyl-gallic acid isomers (3), 1, 2, 3, 4, 6-penta-O-galloyl-β-D-glucose (4), and two inactive phenolic compounds, gallic acid methyl ester (1) and gallic acid (2). Compounds 3 and 4 showed significant hepatoprotective effects with EC_<50> values of 70.39±5.4 and 29.51±0.7μM, respectively, against tacrine-induced cytotoxicity, and 150.9±6.4 and 23.81±0.5μM, respectively, against nitrofurantoin-induced cytotoxicity in Hep G2 cells.
- 公益社団法人日本薬学会の論文
- 2005-11-01
著者
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Kim Youn-chul
中華人民共和国
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Kim Youn-chul
Coll. Of Pharmacy Wonkwang Univ.
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An Ren-bo
韓国
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An Ren-bo
Key Lab. Of Organism Functional Factors Of The Changbai Mountain Coll. Of Pharmacy Yanbian Univ.
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An Ren-bo
Laboratory Of Immunomodulator Korea Research Institute Of Bioscience And Biotechnology
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An Ren
韓国
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An Ren
Laboratory Of Immunomodulator Korea Research Institute Of Bioscience And Biotechnology
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An Ren-bo
College Of Pharmacy Chungnam National University
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Kim Youn-chul
Coll. Of Pharmacy Wonkwang Univ. Kor
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Kim Youn-chul
College Of Pharmacy Medicinal Resources Research Center Wonkwang University
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Kim Youn
College Of Pharmacy Wonkwang University
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AN Ren
College of Pharmacy, Chungnam National University
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Oh Hyuncheol
Mcbi & College Of Natural Sciences Silla University
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