PTP1B Inhibitory Effect of Abietane Diterpenes Isolated from Salvia miltiorrhiza(Pharmacognosy)
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概要
- 論文の詳細を見る
Protein tyrosine phosphatase 1B (PTP1B) acts as a negative regulator of insulin signaling, and selective inhibition of PTP1B has served as a potential drug target for the treatment of type 2 diabetes. In the course of screening for PTP1B inhibitory natural products, the MeOH extract of the dried root of Salvia miltiorrhiza BUNGE (Labiatae) was found to exhibit significant inhibitory effect. Bioassay-guided fractionation and purification afforded three related abietane-type diterpene metabolites 1-3. Compounds 1-3 were identified as isotanshinone IIA (1), dihydroisotanshinone I (2), and isocryptotanshinone (3) mainly by analysis of NMR and MS data. Compounds 1-3 non-competitively inhibited PTP1B activity with 50% inhibitory concentration values of 11.4±0.6μM, 22.4±0.6μM and 56.1±6.3μM, respectively.
- 社団法人日本薬学会の論文
- 2005-09-01
著者
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Kim Bo
Functional Metabolite Research Center Korea Research Institute Of Bioscience And Biotechnology
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Kim Bo
韓国
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OH Won
Korea Research Institute of Bioscience and Biotechnology (KRIBB)
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KIM Bo
Korea Research Institute of Bioscience and Biotechnology (KRIBB)
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AHN Jong
Korea Research Institute of Bioscience and Biotechnology (KRIBB)
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Ahn J
Functional Metabolite Research Center Korea Research Institute Of Bioscience And Biotechnology
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Kim Beom
韓国
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Ahn Jong
Korea Research Institute Of Bioscience And Biotechnology
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OH Hyuncheol
Korea Research Institute of Bioscience and Biotechnology (KRIBB)
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HAN Yu
Korea Research Institute of Bioscience and Biotechnology (KRIBB)
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NA Min
Korea Research Institute of Bioscience and Biotechnology (KRIBB)
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KIM Beom
Korea Research Institute of Bioscience and Biotechnology (KRIBB)
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JEONG Dae
Korea Research Institute of Bioscience and Biotechnology (KRIBB)
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RYU Seong
Korea Research Institute of Bioscience and Biotechnology (KRIBB)
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SOK Dai
College of Pharmacy, Chungnam National Unversity
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Na Minkyun
Korea Res. Inst. Of Bioscience And Biotechnology (kribb)
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Oh Hyuncheol
Mcbi & College Of Natural Sciences Silla University
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Na Min-kyun
College Of Pharmacy Chungnam National University
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Sok Dai
College Of Pharmacy Chungnam National Unversity
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Sok Dai
College Of Pharmacy Chungnam National University
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Jeong Dae
Korea Electrotechnology Research Institute
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Oh Won
Korea Atomic Energy Research Institute
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Oh H
Korea Research Institute Of Bioscience And Biotechnology (kribb)
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Kim Beom
Korea Research Institute Of Bioscience And Biotechnology
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