Anti-Helicobacter pylori Acticvity of Quinolone Alkaloids from Evodiae Fructus
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概要
- 論文の詳細を見る
A biologically monitored fractionation of methanol extract of the fruit of Evodia rutaecarpa led to the isolation of six quinolone alkaloids, evocarpine (1), 1-methyl-2-[(4Z, 7Z)-4,7-tridecadienyl]-4(1H)-quinolone (2), 1-methyl-2-[(6Z, 9Z)-6,9-pentadecadienyl]-4(1H)-quinolone (3), 1-methyl-2-undecyl-4(1H)-quinolone (4), dihydroevocarpine (5), 1-methyl-2-pentadecyl-4(1H)-quinolone (6). They showed potent anti-Helicobacter pylori activity with the minimum inhibitory concentration (MIC) value of 10-20 μg/ml. However, they had no effect on Helicobacter pylori urease activity at the concentration of 300 μg/ml.
- 1999-10-15
著者
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Kim Dong-hyun
College Of Pharmacy Kyung Hee University
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BAE Eun-Ah
College of Pharmacy, Kyung Hee University
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Bae Eun-ah
College Of Pharmacy Kyung Hee University
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Kim Bo
Functional Metabolite Research Center Korea Research Institute Of Bioscience And Biotechnology
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Kim Bo
韓国
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Lee Hyun
韓国
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Lee Hyun
Korea Research Institute Of Bioscience And Biotechnology (kribb)
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RHO Tae
Korea Research Institute of Bioscience and Biotechnology (KRIBB)
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OH Won
Korea Research Institute of Bioscience and Biotechnology (KRIBB)
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KIM Bo
Korea Research Institute of Bioscience and Biotechnology (KRIBB)
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AHN Jong
Korea Research Institute of Bioscience and Biotechnology (KRIBB)
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Lee Ho
Professional Graduate School of Oriental Medicine, Wonkwang University
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Lee H
Bioanalysis Laboratory College Of Pharmacy Wonkwang University
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Ahn J
Functional Metabolite Research Center Korea Research Institute Of Bioscience And Biotechnology
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Kim Beom
韓国
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Ahn Jong
Korea Research Institute Of Bioscience And Biotechnology
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Lee Hyun
Korea Research Institute Of Bioscience And Biotechnology
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Lee Hye
Bioanalysis Laboratory College Of Pharmacy Wonkwang University
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Oh Won
Korea Atomic Energy Research Institute
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Kim Dong-hyun
College Of Pharmacy
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Lee Hyun
Korea Photonics Technology Institute, Gwangju 500-460, Korea
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