In Vitro and in Vivo Antiallergic Effect of the Fructus of Evodia rutaecarpa and Its Constituents(Pharmacognosy)
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概要
- 論文の詳細を見る
The unripe fruit of Evodia rutaecarpa (Juss) BENTH (ER, Family Rutaceae) has been used frequently as a traditional medicine against inflammatory diseases in Korea, China and Japan. To evaluate antiallergic effect of ER, we isolated its main constituents, evodiamine and rutaecarpine, and evaluated in vivo their inhibitory effects against passive cutaenous anaphylaxis (PCA) reaction induced by IgE-antigen complex and scratching behaviors by compound 48/80. ER and its constituents, evodiamine and rutaecarpine, potently inhibited PCA reaction and scratching behaviors in mice, although ER weakly inhibited scratching behaviors. Evodiamine and rutaecarpine inhibited TNF-α and IL-4 protein expression in RBL-2H3 cells induced by IgE-antigen complex, although these did not inhibit degranulation of RBL-2H3 cells induced by IgE-antigen complex and rat peritoneal mast cells induced by compound 48/80. These findings suggest that ER and its constituents, evodiamine and rutaecarpine, may be effective for IgE-induced allergic diseases such as atopic dermatitis and rhinitis.
- 社団法人日本薬学会の論文
- 2007-01-01
著者
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Shin Yong
College Of Pharmacy Kyung Hee University
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Kim Dong-hyun
College Of Pharmacy Kyung Hee University
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BAE Eun-Ah
College of Pharmacy, Kyung Hee University
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SHIN Yong-Wook
College of Pharmacy, Kyung Hee University
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CAI Xing
Korea Research Institute of Bioscience and Biotechnology
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LEE Jung
Korea Research Institute of Bioscience and Biotechnology
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Bae Eun-ah
韓国
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Bae Eun-ah
College Of Pharmacy Kyung Hee University
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Shin Yong-wook
College Of Pharmacy Kyung Hee University
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Choo Min-kyung
韓国
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Shin Yong‐wook
韓国
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Kim D‐h
College Of Pharmacy Kyung Hee University
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Bae E‐a
College Of Pharmacy Kyung Hee University
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Bae Eun-ah
Department Of Life And Nanopharmaceutical Sciences And Department Of Pharmaceutical Science Kyung He
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Han Myung
Dep. Of Food And Nutrition Kyung Hee Univ.
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Cai Xing
Korea Res. Inst. Of Bioscience And Biotechnology Kor
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Kim D‐h
Taegu Univ. Kyungbuk Kor
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Lee Jung
Korea Advanced Institute Of Science And Technology
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Kim Dong-hyun
College Of Pharmacy
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