A Diterpenoid Acanthoic Acid from Acanthopanax koreanum Protects against D-Galactosamine/Lipopolysaccharide-Induced Fulminant Hepatic Failure in Mice(Pharmacology)
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概要
- 論文の詳細を見る
The hepatoprotective effects of a diterpenoid acanthoic acid isolated from Acanthopanax koreanum NAKAI were evaluated in a D-galactosamine/lipopolysaccharide-induced fulminant hepatic failure mouse model. Mice were pretreated orally with acanthoic acid 12 and 1 h before intraperitoneal injection of D-galactosamine and lipopolysaccharide. Pretreatment with the compound markedly reduced lethal liver injury in experimental animals. The effects were likely associated with a significant decrease in serum tumor necrosis factor (TNF)-α levels, which are correlated not only with those of alanine aminotransferase and aspartate aminotransferase but also with the reduced number of apoptotic hepatocytes in the liver as confirmed using the terminal deoxynucleotidyl transferase-mediated dUTP nick end-labeling method and DNA fragmentation assay. These results suggest that acanthoic acid protects against D-galactosamine/lipopolysaccharide-induced fulminant liver failure at least in part by a mechanism associated with the down-regulation of TNF-α secretion.
- 公益社団法人日本薬学会の論文
- 2008-04-01
著者
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CAI Xing
Korea Research Institute of Bioscience and Biotechnology
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LEE Jung
Korea Research Institute of Bioscience and Biotechnology
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Lee Jung
Natural Product Biosynthesis Research Unit Korea Research Institute Of Bioscience & Biotechnolog
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Lee J
Korea Research Institute Of Bioscience And Biotechnology
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Jiang Ying-zi
Key Laboratory Of Organism Functional Factors Of The Changbai Mountain (yanbian University) Ministry
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Lian Li-Hua
Key Laboratory for Natural Resource of Changbai Mountain & Functional Molecules, Ministry of Educati
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Nan Ji-Xing
Key Laboratory for Natural Resource of Changbai Mountain & Functional Molecules, Ministry of Educati
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JIN Xue-Jun
Korea Research Institute of Bioscience and Biotechnology
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JIN Hong
Korea Research Institute of Bioscience and Biotechnology
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Lee J
College Of Pharmacy Chungbuk National University
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Cai Xing
Korea Res. Inst. Of Bioscience And Biotechnology Kor
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Nan Ji-xing
Key Lab. For Natural Resource Of Changbai Mountain & Functional Molecules Ministry Of Education
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Lee Jung
Korea Advanced Institute Of Science And Technology
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Lian Li-hua
Key Laboratory For Natural Resource Of Changbai Mountain & Functional Molecules Ministry Of Educ
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Jin Xue-jun
Key Laboratory For Natural Resource Of Changbai Mountain & Functional Molecules Ministry Of Educ
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