Protective Effects of Salidroside against Acetaminophen-Induced Toxicity in Mice(Pharmacology)

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概要

• 論文の詳細を見る

• The protective effect of salidroside (SDS) isolated from Rhodiola sachalinensis A. BOR. (Crassulaceae), was investigated in acetaminophen (APAP)-induced hepatic toxicity mouse model in comparison to N-acetylcysteine (NAC). Drug-induced hepatotoxicity was induced by an intraperitoneal (i.p.) injection of 300 mg/kg (sub-lethal dose) of APAP. SDS was given orally to mice at a dose of 50 or 100 mg/kg 2 h before the APAP administration in parallel with NAC. Mice were sacrificed 12 h after the APAP injection to determine aspartate aminotransferase (AST), alanine aminotransferase (ALT), and tumor necrosis factor-alpha (TNF-α) levels in serum and glutathione (GSH) depletion, malondialdehyde (MDA) accumulation, and caspase-3 expression in liver tissues. SDS significantly protected APAP-induced hepatotoxicity for SDS improved mouse survival rates better than NAC against a lethal dose of APAP and significantly blocked not only APAP-induced increases of AST, ALT, and TNF-α but also APAP-induced GSH depletion and MDA accumulation. Histopathological and immunohistochemical analyses also demonstrated that SDS could reduce the appearance of necrosis regions as well as caspase-3 and hypoxia inducible factor-1α (HIF-1α) expression in liver tissue. Our results indicated that SDS protected liver tissue from the APAP-induced oxidative damage via preventing or alleviating intracellular GSH depletion and oxidation damage, which suggested that SDS would be a potential antidote against APAP-induced hepatotoxicity.

• 公益社団法人日本薬学会の論文
• 2008-08-01

著者

• Wu Yan-ling

  Key Laboratory Of Organism Functional Factors Of The Changbai Mountain College Of Pharmacy Yanbian U

• Nan Ji-Xing

  Key Laboratory for Natural Resource of Changbai Mountain & Functional Molecules, Ministry of Educati

• Han Xue-hua

  Key Laboratory Of Organism Functional Factors Of The Changbai Mountain College Of Pharmacy Yanbian U

• Piao Dong-ming

  Department Of Pathology The Affiliated Hospital Medical College Yanbian University

• Nan Ji-xing

  Key Lab. For Natural Resource Of Changbai Mountain & Functional Molecules Ministry Of Education

• Nan Ji-xing

  Key Laboratory Of Organism Functional Factors Of The Changbai Mountain College Of Pharmacy Yanbian U

• Wu Yan-ling

  Key Laboratory For Natural Resource Of Changbai Mountain & Functional Molecules Ministry Of Educ

関連論文

• Hepatoprotective Effects of Sedum sarmentosum on D-Galactosamine/Lipopolysaccharide–Induced Murine Fulminant Hepatic Failure
• A Diterpenoid Acanthoic Acid from Acanthopanax koreanum Protects against D-Galactosamine/Lipopolysaccharide-Induced Fulminant Hepatic Failure in Mice(Pharmacology)
• Protective Effects of Salidroside against Acetaminophen-Induced Toxicity in Mice(Pharmacology)
• Hepatoprotective Effects of Sedum sarmentosum on D-Galactosamine/Lipopolysaccharide-Induced Murine Fulminant Hepatic Failure

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