Acylated Flavonol Glycosides with Anti-complement Activity from Persicaria lapathifolia

概要

論文の詳細を見る
During a search for biologically active compounds from traditional medicines, a crude extract of Persicaria lapathifolia was found to have anti-complement activity. Bioassay-guided chromatographic separation of the active constituents led to the isolation of a new acylated kaempferol glycoside (1) and three known acylated quercetin glycosides (2-4). The structures of compounds 1-4 were characterized as kaempferol 3-O-β-D-(6"-p-hydroxybenzoyl)-galactopyranoside, quercetin 3-O-β-D-(6"-feruloyl)-galactopyranoside, quercetin 3-O-β-D-(2"-galloyl)-rhamnopyranoside and quercetin 3-O-β-D-(2"-galloyl)-glucopyranoside, respectively. Compounds 1-4 showed strong anti-complement activity (IC_<50> values of 4.3,9.7,3.9 and 7.6×10^<-5>M, respectively) on the classical pathway of the complement. On the other hand, six isolated flavonol glycosides (5-10) did not show any activity on this system.
社団法人日本薬学会の論文
1999-10-15