Effects of Oleanane-Type Triterpenoids from Fabaceous Plants on the Expression of ICAM-1
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概要
- 論文の詳細を見る
We examined the inhibitory effects of oleanane-type triterpenoids from fabaceous plants on the TNF-α-induced expression of cell adhesion molecules on THP-1 human monocytic leukemia cells and compared them with a glucocorticoid dexamethasone. in a cell-based ELISA, abrisapogenol E, soyasapogenols B and C, soyasapogenol B, kuzusapogenol B-methyl ester, and oleanolic acid significantly inhibited intercellular adhesion molecule (ICAM-1) expression. Moreover, these triterpenoids showed the same activity as dexamethasone. On the other hand, the absence of hydroxyl group at C-24 position of sapogenin rather to increase ICAM-1 expression compared with the untreated control. We concluded that the activity of oleanane saponins and sapogenins against ICAM-1 expression are dependent upon the position of the hydroxyl group, and in particular upon the status of the C-21 and C-24 positions and of the glycosyl group at C-3 position.
- 社団法人日本薬学会の論文
- 2002-08-01
著者
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KINJO Junei
Faculty of Pharmaceutical Sciences, Fukuoka University
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Kinjo Junei
Faculty Of Pharmaceutical Sciences Fukuoka University
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Kinjo Junei
福岡大学 薬学部
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Kinjo Junei
熊本大学 薬
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Lee Hyeong-kyu
韓国
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Lee Hyeong-kyu
Korea Research Institute Of Bioscience And Biotechnology
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Min Byung-sun
Coll. Of Pharmacy Catholic Univ. Of Daegu
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Min B‐s
College Of Pharmacy Catholic University Of Daegu
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金城 順英
熊本大学 薬
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Jung K
Laboratory Of Immunomodulator Korea Research Institute Of Bioscience And Biotechnology
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Min Byung
College Of Pharmacy Catholic University Of Daegu
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Kim J‐h
Korea Res. Inst. Of Bioscience And Biotechnology Daejeon Kor
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Ahn K
Korea Research Institute Of Bioscience And Biotechnology
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AHN Kyung-Seop
Immunomodulator Research Laboratory, Korea Research Institute of Bioscience and Biotechnology
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KIM Jung-Hee
Immunomodulator Research Laboratory, Korea Research Institute of Bioscience and Biotechnology
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OH Sei-Ryang
Immunomodulator Research Laboratory, Korea Research Institute of Bioscience and Biotechnology
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MIN Byung-Sun
Immunomodulator Research Laboratory, Korea Research Institute of Bioscience and Biotechnology
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LEE Hyeong-Kyu
Immunomodulator Research Laboratory, Korea Research Institute of Bioscience and Biotechnology
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Ahn K‐s
Cancer Preventive Material Development Research Center College Of Oriental Medicine Kyunghee Univers
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Ahn Kwang
Cancer Preventive Material Dev. Res. Center Coll. Of Oriental Medicine Kyunghee Univ.
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Kinjo J
Faculty Of Pharmaceutical Sciences Fukuoka University
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Kim J-h
Faculty Of Pharmaceutical Sciences Fukuoka University
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Min Byung-sun
Laboratory Of Immunomodulator Korea Research Institute Of Bioscience And Biotechnology
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Lee Hyeong-kyu
Korea Res. Inst. Of Bioscience And Biotechnology
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Lee Hyeong-kyu
Natural Product Biosynthesis Research Unit Korea Research Institute Of Bioscience & Biotechnolog
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Oh Sei-ryang
Korea Research Institute Of Bioscience And Biotechnology:college Of Pharmacy Wonkwang University
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Ahn K
Seoul National Univ. Seoul Kor
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Lee Hyeong-kyu
Immunomodulator Research Laboratory Korea Research Institute Of Bioscience And Biotechnology
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Kinjyo Junei
Faculty Of Pharmaceutical Sciences Kumamoto University
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Oh Sei-Ryang
Immune Modulator Research Center, Bio-Therapeutics Research Institute, Korea Research Institute of Bioscience & Biotechnology
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Ahn Kyung-Seop
Immune Modulator Research Center, Bio-Therapeutics Research Institute, Korea Research Institute of Bioscience & Biotechnology
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