Oleanene Glycosides of the Aerial Parts and Seeds of Bupleurum falcatum and the Aerial Parts of Bupleurum rotundifolium, and Their Evaluation as Anti-hepatitis Agents
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概要
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To facilitate effective resource utilization, we have investigated triterpene saponins such as saikosaponin from the aerial parts of Bupleurum (B.) falcatum L., which are commonly discarded. Seven oleanene saponins were isolated from this plant; they were classified as the 13,28-epoxy type, 12-ene type, 9(11),12-diene type, and 28-acid type on the basis of their structural characteristics. For comparison, we also examined the oleanene saponins of the seeds of B. falcatum and the aerial parts of B. rotundifolium L. to obtain seven saponins and one sapogenol from the former and thirteen oleanene saponins from the latter. Several compounds obtained from them were investigated for their hepatoprotective activity and hepatotoxicity. The 13,28-epoxy type saponins had hepatoprotectivity. Ursane type showed hepatotoxicity from middle concentration. The 11,13(18)-diene type saponins did not express hepatoprotective activity. The 28-acid type saponin which has a glucosyl carboxy group showed hepatoprotective action.
著者
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Kinjo Junei
Faculty Of Pharmaceutical Sciences Fukuoka University
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Kinjo Junei
東海大学 農学部
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Kinjo Junei
Department Of Pharmacognosy Faculty Of Pharmaceutical Sciences Fukuoka University
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Kinjo Junei
福岡大学 薬学部
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Jung K
Laboratory Of Immunomodulator Korea Research Institute Of Bioscience And Biotechnology
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Okawa Masafumi
Faculty Of Pharmaceutical Sciences Kumamoto University
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Kinjo J
Faculty Of Pharmaceutical Sciences Fukuoka University
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Kim J-h
Faculty Of Pharmaceutical Sciences Fukuoka University
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Jung K
Korea Res. Inst. Biosci. And Biotechnol. Taejon Kor
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Nohara Toshihiro
Faculty Of Medical And Pharmaceutical Science Kumamoto University
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Kinjyo Junei
Faculty Of Pharmaceutical Sciences Kumamoto University
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Ono Masateru
School Of Agriculture Kyushu Tokai University
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Okawa Masafumi
Faculty Of Pharmaceutical Sciences Fukuoka University
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Nakajima Y
Tsukuba Research Institute Ohta's Isan Co. Ltd.
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Nakahara Yuko
Graduate School of Pharmaceutical Sciences, Faculty of Life Sciences, Kumamoto University
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Nohara Toshihiro
Faculty of Medical and Pharmaceutical Scieces, Sojo University
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