Anti-complement Activity of Constituents from the Stem-Bark of Juglans mandshurica
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概要
- 論文の詳細を見る
Four known flavonoids and two galloyl glucoses isolated from the stem-bark of Juglans mandshurica (Juglandaceae), namely taxifolin (1), afzelin (2), quercitrin (3), myricitrin (4), 1,2,6-trigalloylglucose (5), and 1,2,3,6-tetragalloylglucose (6), were evaluated for their anti-complement activity against complement system. Afzelin (2) and quercitrin (3) showed inhibitory activity against complement system with 50% inhibitory concentrations (IC_<50>) values of 258 and 440 μM. 1,2,6-Trigalloylglucose (5) and 1,2,3,6-tetragalloylglucose (6) exhibited anti-complement activity with IC_<50> values of 136 and 34μM . In terms of the evaluation of the structure-activity relationship of 3,5,7-trihydroxyflavone, compounds 2, 3, and 4 were hydrolyzed with naringinase to give kaempferol (2a), quercetin (3a), and myricetin (4a) as their aglycones, and these were also tested for their anti-complement activity. Of the three aglycones, kaempferol (2a) exhibited weak anti-complement activity with an IC_<50> value of 730μM , while quercetin (3a) and myricetin (4a) were inactive in this assay system. Among the compounds tested, 1,2,3,6-tetragalloylglucose (6) showed the most potent anticomplement activity (IC_<50>, 34μM).
- 公益社団法人日本薬学会の論文
- 2003-07-01
著者
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Kim Dong-hyun
Td Team R&d Center Samsung Electronics Co.ltd.
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Kinjo Junei
福岡大学 薬学部
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Kinjo Junei
熊本大学 薬
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Lee Hyeong-kyu
韓国
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Lee Hyeong-kyu
Korea Research Institute Of Bioscience And Biotechnology
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Kim Doo-young
School Of Electrical Eng. Seoul National Univ.
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Min Byung-sun
Coll. Of Pharmacy Catholic Univ. Of Daegu
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Min B‐s
College Of Pharmacy Catholic University Of Daegu
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Min Byung
Institute Of Natural Medicine Toyama Medical And Pharmaceutical University
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Nakamura Norio
Institute Of Natural Medicine University Of Toyama
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Lee S‐y
Kt&g Central Research Institute
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HATTORI Masao
Institute of Natural Medicine, University of Toyama
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Jung K
Laboratory Of Immunomodulator Korea Research Institute Of Bioscience And Biotechnology
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Nakamura N
Faculty Of Pharmaceutical Sciences Doshisha Women's College Of Liberal Arts
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KIM Young-Ho
College of Pharmacy, Chungnam National University
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Kim Y‐h
Samsung Electronics Co. Ltd Gyeonggi‐do Kor
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Lee Hyeong-kyu
Laboratory Of Immunomodulator Korea Research Institute Of Bioscience And Biotechnology
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Kim Dong-hee
Korea Research Institute Of Bioscience And Biotechnology
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Lee Sun-young
Department Of Oriental Pharmaceutical Science And Kyung Hee East-west Pharmaceutical Research Instit
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MIYASHIRO Hirotsugu
Institute of Natural Medicine, University of Toyama
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Min Byung
College Of Pharmacy Catholic University Of Daegu
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Kim Do-hoon
Department Of Psychiatry College Of Medicine Institute Of Natural Medicine Hallym University
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Kim J‐h
Korea Res. Inst. Of Bioscience And Biotechnology Daejeon Kor
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KIM Tae-Jin
Korea Research Institute of Bioscience and Biotechnology
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Nakamura N
Institute Of Natural Medicine Toyama Medical And Pharmaceutical University
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Lee Joong-ku
Laboratory Of Immunomodulator Korea Research Institute Of Bioscience And Biotechnology
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Kim Young-ho
College Of Pharmacy Chungnam National University
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Kinjo J
Faculty Of Pharmaceutical Sciences Fukuoka University
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Kim J-h
Faculty Of Pharmaceutical Sciences Fukuoka University
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Min Byung-sun
Laboratory Of Immunomodulator Korea Research Institute Of Bioscience And Biotechnology
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Jung K
Korea Res. Inst. Biosci. And Biotechnol. Taejon Kor
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Lee Hyeong-kyu
Korea Res. Inst. Of Bioscience And Biotechnology
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Lee Hyeong-kyu
Natural Product Biosynthesis Research Unit Korea Research Institute Of Bioscience & Biotechnolog
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KIM Jung-Hee
Laboratory of Immunomodulator, Korea Research Institute of Bioscience and Biotechnology
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LEE Sun-Young
Laboratory of Immunomodulator, Korea Research Institute of Bioscience and Biotechnology
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KIM Tae-Jin
Laboratory of Immunomodulator, Korea Research Institute of Bioscience and Biotechnology
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KIM Dong-Hee
Laboratory of Pathology, College of Oriental Medicine, Deajeon University
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JOUNG Hyouk
Laboratory of Immunomodulator, Korea Research Institute of Bioscience and Biotechnology
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Joung Hyouk
Laboratory Of Immunomodulator Korea Research Institute Of Bioscience And Biotechnology
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Kim D‐h
College Of Pharmacy Kyung-hee University
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Min Byung
Laboratory Of Immunomodulator Korea Research Institute Of Bioscience And Biotechnology
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Kim D‐h
Department Of Psychiatry College Of Medicine Institute Of Natural Medicine Hallym University
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Kinjyo Junei
Faculty Of Pharmaceutical Sciences Kumamoto University
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Lee S‐m
Kyung‐hee Univ. Seoul Kor
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Hattori Masao
Institute Of Natural Medicine Faculty Of Pharmaceutical Sciences
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Miyashiro H
Institute Of Natural Medicine University Of Toyama
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Nakamura Norio
Institute Of Natural Medicine Toyama And Pharmaceutical University
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Nakamura Norio
Institute Of Natural Medicine
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