Anti-complement Activity of Tiliroside from the Flower Buds of Magnolia fargesii
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概要
- 論文の詳細を見る
As part of the search for anticomplemertary active components from natural products, the anticomplementary properties of methanolic extracts from the flower buds of Magnolia fargesii have been investigated. Bioassayguided chromatographic separation of the active consituents led to the isolation of compound 1,whose structure was identified by spectroscopic methods to be kaempferol 3-O-β-D-(6"-O-coumaroyl)glucopyranoside (tiliroside). Tiliroside showed very potent anti-complement activity (IC_<50>=5.4×10^<-5> M) on the classical pathway of the complement system, even higher than rosmarinic acid, which is a well-known inhibitor against the complement system. On the other hand, the hydrolysates of tiliroside, kaempferol, astragalin and p-coumaric acid showed very weak activity on this system.
- 社団法人日本薬学会の論文
- 1998-10-15
著者
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Kinjo Junei
熊本大学 薬
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Lee Hyeong-kyu
韓国
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Lee Hyeong-kyu
Korea Research Institute Of Bioscience And Biotechnology
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Lee Im
Natural Product Biosynthesis Research Unit Korea Research Institute Of Bioscience & Biotechnolog
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Lee Jung
Natural Product Biosynthesis Research Unit Korea Research Institute Of Bioscience & Biotechnolog
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Lee J
Korea Research Institute Of Bioscience And Biotechnology
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Ahn K
Korea Research Institute Of Bioscience And Biotechnology
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JUNG Keun
Natural Product Biosynthesis Research Unit, Korea Research Institute of Bioscience and Biotechnology
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OH Sei
Natural Product Biosynthesis Research Unit, Korea Research Institute of Bioscience and Biotechnology
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PARK Si-Hyung
Natural Product Biosynthesis Research Unit, Korea Research Institute of Bioscience and Biotechnology
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AHN Kyung
Natural Product Biosynthesis Research Unit, Korea Research Institute of Bioscience and Biotechnology
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LEE Hyeong-Kyu
Natural Product Biosynthesis Research Unit, Korea Research Institute of Bioscience and Biotechnology
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Park Si-hyung
Natural Product Biosynthesis Research Unit Korea Research Institute Of Bioscience & Biotechnolog
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Ahn K‐s
Cancer Preventive Material Development Research Center College Of Oriental Medicine Kyunghee Univers
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Ahn Kwang
Cancer Preventive Material Dev. Res. Center Coll. Of Oriental Medicine Kyunghee Univ.
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Jung K
Korea Res. Inst. Biosci. And Biotechnol. Taejon Kor
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Lee Hyeong-kyu
Korea Res. Inst. Of Bioscience And Biotechnology
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Lee Hyeong-kyu
Natural Product Biosynthesis Research Unit Korea Research Institute Of Bioscience & Biotechnolog
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Lee J
College Of Pharmacy Chungbuk National University
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Lee J
Anticancer Research Laboratory Korea Research Institute Of Bioscience And Biotechnology
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Oh Sei-ryang
Korea Research Institute Of Bioscience And Biotechnology:college Of Pharmacy Wonkwang University
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Oh Sei
Natural Product Biosynthesis Research Unit Korea Research Institute Of Bioscience & Biotechnolog
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Ahn K
Seoul National Univ. Seoul Kor
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Lee I
Korea Res. Inst. Biosci. And Biotechnol. Taejon Kor
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Ahn Kyung
Natural Product Biosynthesis Research Unit Korea Research Institute Of Bioscience & Biotechnolog
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