Increase of Caspase-3 Activity by Lignans from Machilus thunbergii in HL-60 Cells(Pharmacognosy)

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概要

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• Nine lignans and two butanolides were isolated from the stem bark of Machilus thunbergii and their structures were identified as machilin A (1), licarin B (2), zuonin B (3), macelignan (4), secoisolancifolide (5), isolancifolide (6), oleiferin C (7), meso-dihydroguaiaretic acid (8), licarin A (9), machilin F (10), and nectandrin B (11) by spectroscopic means. These compounds were assessed for their abilities to activate a caspase-3 activity in human promyeloid leukemic HL-60 cells. The intracellular caspase-3 activity of macelignan (4), oleiferin C (7), meso-dihydroguaiaretic acid (8), and licarin A (9) increased approximately 3.04, 6.16, 2.10, and 3.10-fold at 100μM over that of untreated control. In addition, compounds 4, 7, 8, and 9 induced internucleosomal DNA fragmentation in HL-60 cells.

• 社団法人日本薬学会の論文
• 2004-08-01

著者

• Kim Dong-hyun

  Td Team R&d Center Samsung Electronics Co.ltd.

• Lee Hyeong-kyu

  韓国

• Lee Hyeong-kyu

  Korea Research Institute Of Bioscience And Biotechnology

• Kim Doo-young

  School Of Electrical Eng. Seoul National Univ.

• Min Byung-sun

  Coll. Of Pharmacy Catholic Univ. Of Daegu

• Min B‐s

  College Of Pharmacy Catholic University Of Daegu

• Min Byung

  Institute Of Natural Medicine Toyama Medical And Pharmaceutical University

• Kim Dong-hee

  Korea Research Institute Of Bioscience And Biotechnology

• Min Byung

  College Of Pharmacy Catholic University Of Daegu

• Min Byung-sun

  Korea Research Institute Of Bioscience And Biotechnology

• Kim Do-hoon

  Department Of Psychiatry College Of Medicine Institute Of Natural Medicine Hallym University

• Ahn K

  Korea Research Institute Of Bioscience And Biotechnology

• KWON Ok-Kyoung

  Korea Research Institute of Bioscience and Biotechnology

• PARK Bo-Young

  Korea Research Institute of Bioscience and Biotechnology

• OH Sei-Ryang

  Korea Research Institute of Bioscience and Biotechnology

• AHN Kyung-Seop

  Korea Research Institute of Bioscience and Biotechnology

• KIM Tae-Jin

  Korea Research Institute of Bioscience and Biotechnology

• KIM Doo-Young

  Korea Research Institute of Bioscience and Biotechnology

• BAE KiWhan

  College of Pharmacy, Chungnam National University

• Ahn K‐s

  Cancer Preventive Material Development Research Center College Of Oriental Medicine Kyunghee Univers

• Ahn Kwang

  Cancer Preventive Material Dev. Res. Center Coll. Of Oriental Medicine Kyunghee Univ.

• Min Byung-sun

  Laboratory Of Immunomodulator Korea Research Institute Of Bioscience And Biotechnology

• Lee Hyeong-kyu

  Korea Res. Inst. Of Bioscience And Biotechnology

• Lee Hyeong-kyu

  Natural Product Biosynthesis Research Unit Korea Research Institute Of Bioscience & Biotechnolog

• Kim D‐h

  College Of Pharmacy Kyung-hee University

• Min Byung

  Laboratory Of Immunomodulator Korea Research Institute Of Bioscience And Biotechnology

• Kim D‐h

  Department Of Psychiatry College Of Medicine Institute Of Natural Medicine Hallym University

• Oh Sei-ryang

  Korea Research Institute Of Bioscience And Biotechnology:college Of Pharmacy Wonkwang University

• Ahn K

  Seoul National Univ. Seoul Kor

• Bae Kiwhan

  College Of Pharmacy Chungnam National University

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