Triterpenes from the Spores of Ganoderma lucidum and Their Inhibitory Activity against HIV-1 Protease
スポンサーリンク
概要
- 論文の詳細を見る
Two new lanostane-type triterpenes, lucidumol A and ganoderic acid β, were isolated from the spores of Ganoderma (G.) lucidum, together with a new natural one and seven that were known. The structures of the new triterpenes were determined as (24S)-24,25-dihydroxylanost-8-ene-3,7-dione and 3β, 7β-dihydroxy-11,15-dioxolanosta-8,24(E)-dien-26-oic acid, respectively, by chemical and spectroscopic means. The quantitative analyses of 5 fruiting bodies, antlered form and spores of G. lucidum were performed by high performance liquid chromatography and demonstrated that ganoderic alcohol and acid contents were quite high in the spore. Of the compound isolated, ganoderic acid β, (24S)-lanosta-7,9(11)-diene-3β, 24,25-triol (called lucidumol B), ganodermanondiol, ganodermanontriol and ganolucidic acid A showed significant anti-human immunodeficiency virus (anti-HIV)-1 protease activity with IC_<50> values of 20-90 μM.
- 社団法人日本薬学会の論文
- 1998-10-15
著者
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Min Byung-sun
Coll. Of Pharmacy Catholic Univ. Of Daegu
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Min B‐s
College Of Pharmacy Catholic University Of Daegu
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Min Byung
Institute Of Natural Medicine Toyama Medical And Pharmaceutical University
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花岡 美代次
金沢大学薬学部
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Hattori Masao
Institute Of Natural Medicine University Of Toyama
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Hattori Masao
Research Institute For Wakan-yaku (traditional Sino-japanese Medicines) Toyama Medical And Pharmaceu
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NAKAMURA Norio
Research Institute for Wakan-Yaku, Toyama Medical and Pharmaceutical University
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MIYASHIRO Hirotsugu
Institute of Natural Medicine, University of Toyama
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MIYASHIRO Hirotsugu
Research Institute for Wakan-Yaku (Traditional Sino-Japanese Medicines), Toyama Medical and Pharmace
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MIN Byung-Sun
Research Institute for Traditional Sino-Japanese Medicine, Toyama Medical and Pharmaceutical Univers
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BAE Ki-Whan
College of Pharmacy, ChungNam National University
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Min Byung
College Of Pharmacy Catholic University Of Daegu
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Nakamura N
Institute Of Natural Medicine Toyama Medical And Pharmaceutical University
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Bae Ki-whan
College Of Pharmacy Chungnam National University
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Hattori Masao
Metabolic Engineering Institute Of Natural Medicine University Of Toyama
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Miyashiro H
Institute Of Natural Medicine University Of Toyama
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Nakamura Norio
Research Institute For Wakan-yaku (oriental Medicines) Toyama Medical And Pharmaceutical University
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花岡 美代次
Institute Of Natural Medicine University Of Toyama
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HATTORI MASAO
Research Institute for Wakan-Yaku (Oriental Medicines)
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