A NOVEL AND HIGHLY STEREOSELECTIVE SYNTHESIS OF (±)-SIBIRICINE
スポンサーリンク
概要
- 論文の詳細を見る
A novel and stereoselective synthesis of (±)-sibiricine (1), a spirobenzylisoquinoline alkaloid, from the corresponding protoberberine (3) was developed using photo-oxygenation and photo-isomerization.
- 公益社団法人日本薬学会の論文
- 1985-06-25
著者
-
花岡 美代次
金沢大学薬学部
-
花岡 美代次
Faculty Of Pharmaceutical Sciences Osaka University
-
花岡 美代次
Faculty Of Pharmaceutical Sciences Kanazawa University
-
安田 信吾
金沢大・薬
-
安田 信吾
Faculty of Pharmaceutical Sciences, Kanazawa University
-
神津 真澄
Faculty of Pharmaceutical Sciences, Kanazawa University
-
神津 真澄
Faculty Of Pharmaceutical Sciences Kanazawa University
関連論文
- Studies on Antispasmodics. VI. Synthesis of N-Alkyl 6- and 7-Diarylmethyleneindolizidinium Bromides
- Studies on Antispasmodics. V. Synthesis and Anticholinergic Activity of N-Alkyl 1- and 2-Diarylmethylene-indolizidinium Bromides
- 鎮痙剤の研究(第4報)Diarylhydroxymethylquinolizidine Methohalidesの合成と抗アセチルコリン作用
- 鎮痙剤の研究(第3報)2位置換Quinolizidine類の簡便な新合成法とそれらの立体構造について
- 鎮痙剤の研究(第2報)3位置換Quinolizidine類の簡便な新合成法とそれらの立体構造について
- Studies on 1-Azabicyclo Compounds. XXVI. Synthesis of Ten-membered Ring Amines from 9a-Cyanomethyl-, 9a-Ethoxycarbonylmethyl-, and 1-Ethoxycarbonyl-octahydroquinolizine
- 4 Securinine及びVirosecurinineの全合成
- Total Synthesis of Securinine
- Synthesis of (±)-Methyldecamine
- Dacarbazineの光分解によって生成する発痛物質の探索
- Convenient Synthesis of 2,3,9,10-Tetraoxygenated Protoberberine Alkaloids and Their 13-Methyl Alkaloids
- 12-3-B3 ダカルバジン注射剤投与時における血管痛原因物質の探索
- 100(P24) 抗腫瘍性スチリルラクトン化合物の高立体選択的合成(ポスター発表の部)
- (o-トリメチルシリルベンズアルデヒド)クロム錯体を活用する高立体選択的反応の開発
- Erythro-Selective Aldol Reaction of Tricarbonyl(η^6-o-trialkylsilylbenzaldehyde)chromium(0) Complexes with Cyclic Ketene Silyl Acetals
- 18 Protoberberineアルカロイドの新規合成とBenzo[c]phenanthridineアルカロイド(±)-Ambinineの全合成(口頭発表の部)
- Chemical Transformation of Protoberberines. XVII. Biomimetic Introduction of an Oxy Functionality at the C-10 Position in the Benzo[c]phenanthridine Skeleton : Synthesis of 2,3,7,8,10-Pentaoxygenated Benzo[c]phenanthridine Alkaloids, Chelilutine and Sangu
- A FIRST TOTAL SYNTHESIS OF (±)-AMBININE
- Chemical Transformation of Protoberberines. XVI. Regioselective Introduction of an Oxy Functionality at the C_-Position of the Benzo[c]phenanthridine Skeleton : A Convenient Synthesis of Macarpine from Oxychelirubine
- Trimethylsilyl Trifluoromethanesulfonate-Catalyzed Aldol Reaction of Various Aldehydes with Silyl Enol Ethers
- A NOVEL DIASTEREOSELECTIVITY IN THE ALDOL REACTION OF CYCLIC KETENE SILYL ACETALS WITH COBALT-COMPLEXED AND UNCOMPLEXED PROPYNALS
- 1,6-Dihydro-3 (2H)-pyridinones. II. Synthesis of 2-Azabicyclo [2. 2. 2] octanes by the Reaction of N-Substituted 1,6-Dihydro-3 (2H)-pyridinones with 1,3-Dicarbonyl Compounds
- 1,6-Dihydro-3 (2H)-pyridinones. I. Facile Synthesis of N-Substituted 1,6-Dihydro-3 (2H)-pyridinones
- 含窒素共役系の反応(第8報)Dimethyl Inidazole-4,5-dicarboxylateとAnetholeとの反応生成物の構造について
- 学術貢献賞受賞 北 泰行氏の業績
- 故荒田義雄先生を偲んで
- イソキノリンアルカロイドの生合成的合成
- サマリーを重要視(キーワードの使い方)
- 科学研究費の配分について(文部省科学研究費申請と配分の問題点)
- 双環状アミン体から中環状アミン類の合成
- Synthetic Studies on Lythraceae Alkaloids. V. Total Synthesis of (±)-Vertaline
- Synthetic Studies on Lythraceae Alkaloids. IV. Total Synthesis of (±)-Methyldecinine
- Total Synthesis of (±)-Lagerine
- Synthetic Studies on Lythraceae Alkaloids. III. Stereoselective Total Synthesis of (±)-Decaline
- Synthetic Studies on Lythraceae Alkaloids. II. The Mannich Reaction of Isopelletierine with 3-Methoxybenzaldehyde and 3-Hydroxybenzaldehyde
- Studies on 1-Azabicyclo Compounds. XXIV. Synthesis and Stereochemistry of 10-Ethyl-, 10-Vinyl-, and 10-Ethynyl-quinolizidine Methiodides
- Studies on 1-Azabicyclo Compounds. XXII. Stereochemistry of 9a-Substituted Quinolizidine Methiodides
- Chemical Transformation of Protoberberines. XV. : A Novel and Efficient Method for the Introduction of Alkyl Groups on the C-13 Position in the Protoberberine Skeleton
- A NOVEL TOTAL SYNTHESIS OF (±)-CRYPTAUSTOLINE, A DIBENZOPYRROCOLINE ALKALOID
- A NOVEL AND BIOMIMETIC SYNTHESIS OF CHELILUTINE AND SANGUILUTINE
- A TOTAL SYNTHESIS OF (±)-CEPHALOTAXINAMIDE
- 64 ProtoberberineアルカロイドからBenzo [c] phenanthridineアルカロイドの生合成的合成(口頭発表の部)
- 58 ProtoberberineアルカロイドからBenzo[c]phenanthridineアルカロイドの高立体選択的合成
- 33 ProtoberberineからBenzo〔c〕phenanthridine及び3-Arylisoquinolineアルカロイドの合成
- Chemical Transformation of Protoberberines. VIII. A Novel Synthesis of (±)-Fumaricine and a Formal Synthesis of (±)-Alpinigenine
- Chemical Transformation of Protoberberines. VII. Efficient Conversion of Protoberberines into Benzindenoazepines via 8,14-Cycloberbines
- Chemical Transformation of Protoberberines. V. Photochemical Valence Isomerization of Berberinephenolbetaines to 8,14-Cycloberbines, Versatile Aziridine Derivatives for a Novel and Efficient Entry to Spirobenzylisoquinolines and Benzindenoazepines
- Chemical Transformation of Protoberberines. XIII. A Novel and Efficient Synthesis of Antitumor Benzo[c]phenanthridine Alkaloids, Nitidine and Fagaronine(Organic,Chemical)
- Chemical Transformation of Protoberberines. XI. A Novel Synthesis of 2,3,10,11-Tetraoxygenated Protoberberine Alkaloids from Corresponding 2,3,9,10-Tetraoxygenated Protoberberine Alkaloids(Organic,Chemical)
- SYNTHESIS OF FAGARIDINE, A PHENOLIC BENZO [c] PHENANTHRIDINE ALKALOID
- Two New Triterpenes from the Rhizome of Dryopteris crassirhizoma, and Inhibitory Activities of Its Constituents on Human Immunodeficiency Virus-1 Protease
- Enantioselective Dehydroxylation of Enterodiol and Enterolactone Precursors by Human Intestinal Bacteria(Pharmacognosy)
- Developing of anti-HIV agents from natural resources(Chemical & Pharmacological study)
- A New Enzyme Immunoassay for Aconitine and Its Application to Quantitative Determination of Aconitine Levels in Plasma(Pharmacognosy)
- Sesquiterpenes and Alkaloids from Lindera chunii and Their Inhibitory Activities against HIV-1 Integrase
- Flavanone and Flavonol Glycosides from the Leaves of Thevetia peruviana and Their HIV-1 Reverse Transcriptase and HIV-1 Integrase Inhibitory Activities
- Inhibition of Cytopathic Effect of Human Immunodeficiency Virus Type-1 by Various Phorbol Derivatives
- Inhibitory effects of flavonoids on human immunodeficiency virus type-I integrase
- The Heterocyclic Ring Fission and Dehydroxylation of Catechins and Related Compounds by Eubacterium sp.Strain SDG-2, a Human Intestinal Bacterium
- Triterpenes from the Spores of Ganoderma lucidum and Their Cytotoxicity against Meth-A and LLC Tumor Cells
- Inhibition of Human Immunodeficiency Virus Type 1 Reverse Transcriptase and Ribonuclease H Activites by Constituents of Juglans mandshurica
- Inhibitory Effects of Constituents from Cynomorium songaricum and Related Triterpene Derivatives on HIV-1 Protease
- Triterpenes from the Spores of Ganoderma lucidum and Their Inhibitory Activity against HIV-1 Protease
- Isolation and Characterization of a Human Intestinal Bacterium, Eubacterium sp. ARC-2, Capable of Demethylating Arctigenin, in the Essential Metabolic Process to Enterolactone(Pharmacology)
- Inhibitory effect of Yunnan traditional medicines on hepatitis C viral polymerase
- Isolation of a Human Intestinal Bacterium That Transforms Mangiferin to Norathyriol and Inducibility of the Enzyme That Cleaves a C-Glucosyl Bond(Pharmacognosy)
- An Improved Synthesis of Butyl 4-[(4-Amino-5-chloro-2-methoxybenzoyl)amino]-1-piperidineacetate (AU-224)
- Synthesis and Gastrointestinal Prokinetic Activity of Novel Benzamide Derivatives with Amphoteric Side Chains
- New Triterpenoid Saponins from the Roots of Sinocrassula asclepiadea
- INVERSION OF A HYDROXYL GROUP BY THE NEIGHBORING-GROUP PARTICIPATION OF A URETHANE : A GENERAL AND STEREOSELECTIVE SYNTHESIS OF (±)-RADDEANONE, (±)-YENHUSOMIDINE, AND RELATED SPIROBENZYLISOQUINOLINE ALKALOIDS
- A CONVENIENT TRANSFORMATION OF SPIROBENZYLISOQUINOLINES TO DEHYDROPHTHALIDEISOQUINOLINES
- Chemical Transformation of Protoberberines. XII. : A Novel Synthesis of Rhoeadine Alkaloids. : An Alternative Synthesis of a Key Intermediate, Benzindenoazepine, for a Synthesis of (±)-cis-Alpinigenine and (±)-cis-Alpinine from Palmatine(Organic,Chemical)
- A FIRST AND STEREOSELECTIVE SYNTHESIS OF (±)-RADDEANAMINE
- A NOVEL AND HIGHLY STEREOSELECTIVE SYNTHESIS OF (±)-SIBIRICINE
- Chemical Transformation of Protoberberines. VI. Ring D Inversion of Protoberberine Alkaloids. Conversion of Berberine into Non-naturally Occurring 11,12-Oxygenated Protoberberines via Spirobenzylisoquinolines
- 54 8,14-Cycloberbineを経由するProtoberberineアルカロイドからSpirobenzylisoquinoline及びBenzindenoazepineアルカロイドの合成
- 26 Lythraceaeアルカロイドの合成 : (±)-Decaline,(±)-Vertaline,(±)-Desmethyldecaline,(±)-Methyldecinine,(±)-Methyllagerineの全合成
- Withanolide Derivatives from the Roots of Withania somnifera and Their Neurite Outgrowth Activities
- Trigonelline-Induced Neurite Outgrowth in Human Neuroblastoma SK-N-SH Cells
- Biotransformation of Phorbol by Human Intestinal Bacteria
- 1-Azabicyclo化合物の研究(第21報)1,2,3,10,11,11a-Hexahydro-5H-pyrrolo-[2,1-c][1,4]benzodiazepin-11-oneおよび5,6,6a, 7,8,9,10,12-Octahydropyrido[2,1-c][1,4]benzodiazepin-6-oneから中環状AminolactamおよびSpiroaminolactam体の合成
- Synthesis of (±)-Desmethyldecaline
- Synthesis of the Compound proposed as the Structure of Lagerine and Its Non identity with Lagerine
- Synthesis of (±)-Methyldecinine
- Lythraceaeアルカロイドの合成研究(第1報)Isopelletierineの一改良合成
- Total Synthesis of (±)-Vertaline
- Studies on 1-Azabicyclo Compounds. XVIII. Synthesis of Fourteenmembered Ring Diamine, 1,8-Dimethyl-1,8-diazacyclotetradecane, and Related Compounds from Perhydrodipyrido [1,2-a : 1', 2'-d]-pyrazine via Ten-membered Ring Diamine, 2-Methyl-perhydro-2H-pyrid
- Studies on 1-Azabicyclo Compounds. XVI. Synthesis of 1'-Methylindan-2-spiro-2'-piperazine and Related Compounds
- Studies on 1-Azabicyclo Compounds. XV. Oxidation of 1,3,4,6,11,11a-Hexahydro-2H-pyrazino [1,2-b] isoquinolin-1-one Derivatives with Mercuric Acetate, and Their Conversion into 1,2,3,4,5,6,7,8-Octahydro-2-methyl-2,5-benzodiazecine and Related Compounds
- 1,6-Dihydro-3 (2H)-pyridinones. X. 2-Azabicyclo [2.2.2] octane Ring Formation via Intramolecular Michael Reaction : Total Synthesis of (±)-Ibogamine and (±)-Epiibogamine
- 1,6-Dihydro-3 (2H)-pyridinones. IX. A Regioselective Synthesis of Ethyl 3-Methoxycarbonylmethyl-4-oxopiperidine-1-carboxylate from Ethyl 3-Hydroxy-1,2,3,6-tetrahydropyridine-1-carboxylate
- Alkyne-Co2(CO)6錯体を用いる高立体選択的反応の開発
- ジヒドロピリジノンを共通出発原料としたアルカロイド類の合成
- 双環状アミン体から中環状アミン類の合成
- Constituents of the seeds of Glycyrrhiza uralensis
- Screening of Some Indonesian Medicinal Plants for Inhibitory Effects on HIV-1 Protease
- A Comparative Study on the Inhibitory Effects of Flavonoids and Alkaloids on Reverse Transcriptases of Different Retroviruses
- Effects of Flavonoids and Alkaloids on Reverse Transcriptase
- Effects of Ganoderma lucidum Extracts and Their Constituents on the Spontaneous Beating of Myocardial Cell Sheet in Culture
- ラクトン系ミソハギ科アルカロイドの合成