Inhibition of Human Immunodeficiency Virus Type 1 Reverse Transcriptase and Ribonuclease H Activites by Constituents of Juglans mandshurica
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概要
- 論文の詳細を見る
From the stem-bark of Juglans mandshurica, two new naphthalenyl glucopyranosides, 1,4,8-trihydroxy-nahthalene 1-O-[α-L-arabinofuranosyl-(1→6)-β-D-glucopyranoside] (1) and 1,4,8-trihydroxynaphthalene 1-O-β-D[6'-O-(3", 5"-dihydroxy-4"-methoxybenzoyl)]glucopyranoside (4), and two new α-tetralonyl glucopyranosides, 4α, 5,8-trihydroxy-α-tetralone 5-O-β-D-[6'-O-(3", 5"-dihydroxy-4"-methoxybenzoyl)glucopyranoside (7) and 4α, 5,8-trihydroxy-α-tetralone 5-O-β-D-[6'-O-(3", 4", 5"-trihydroxybenzoyl)glucopyranoside (8), were isolated together with three known naphthalenyl glucopyranosides (2,3 and 5), one α-tetralonyl glucopyranoside (6), four flavonoids (9-12), and two gaalloyl glucopyranosides (13,14).Amongst the isolated compounds, 1,2,6-trigalloylglucopyranose (13) and 1,2,3,6-tertagalloylglucopyranose (14) exhibited the most potent inhibition of reverse transcriptase (RT) activity with IC_<50> values of 0.067 and 0.040 μM, respectively, while the latter compound also inhibited ribonuclease H (RNase H) activity with an IC_<50> of 39 μM, comparable in potency to illimaquinone used as a positive contorl. 1,4,8-Trihydroxy-naphthalene 1-O-β-D-glucopyranoside (2), 1,4,8-trihydroxynaphthalene 1-O-β-D-[6'-O-(4"-hydroxy-3", 5"-dimethoxybenzoyl)]glu-copyranoside (3) and 8 showed moderate inhibition against both enyzme activities, and inhibitory potency of 2 against RNase H activity (IC_<50>=156 μM) was slightly greater than that against the RT activity (IC_<50>=290 μM).The inhibitory potencies of 4α, 5,8-trihydroxy-α-tetralone 5-O-β-D-[6'-O-4"-hydroxy-3", 5"-dimethoxybenzoyl)] glucopyranoside (6), 7 and 8 against RT activity increased accompanied by an increase in the number of free hydroxyls on the galloyl residues, as represented by the IC_<50> values of >500,330 and 5.8 μM, respectively.
- 社団法人日本薬学会の論文
- 2000-02-01
著者
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Min Byung-sun
Coll. Of Pharmacy Catholic Univ. Of Daegu
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Min B‐s
College Of Pharmacy Catholic University Of Daegu
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Min Byung
Institute Of Natural Medicine Toyama Medical And Pharmaceutical University
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花岡 美代次
金沢大学薬学部
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Nakamura Norio
Institute Of Natural Medicine University Of Toyama
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HATTORI Masao
Institute of Natural Medicine, University of Toyama
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MIN Byung-Sun
Institute of Natural Medicine, Toyama Medical and Pharmaceutical University
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KIM Young-Ho
College of Pharmacy, Chungnam National University
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Kim Y‐h
Samsung Electronics Co. Ltd Gyeonggi‐do Kor
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Hattori Masao
Institute Of Natural Medicine University Of Toyama
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MIYASHIRO Hirotsugu
Institute of Natural Medicine, University of Toyama
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Min Byung
College Of Pharmacy Catholic University Of Daegu
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Nakamura N
Institute Of Natural Medicine Toyama Medical And Pharmaceutical University
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Kim Young-ho
College Of Pharmacy Chungnam National University
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Hattori Masao
Institute Of Natural Medicine Faculty Of Pharmaceutical Sciences
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Hattori Masao
Metabolic Engineering Institute Of Natural Medicine University Of Toyama
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Miyashiro H
Institute Of Natural Medicine University Of Toyama
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Nakamura Norio
Institute Of Natural Medicine Toyama And Pharmaceutical University
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Nakamura Norio
Institute Of Natural Medicine
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花岡 美代次
Institute Of Natural Medicine University Of Toyama
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