Kaempferol Acetylrhamnosides from the Rhizome of Dryopteris crassirhizoma and Their Inhibitory Effects on Three Different Activities of Human Immunodeficiency Virus-1 Reverse Transcriptase

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Three new kaempferol glycosides, called crassirhizomosides A(1), B(2)and C(3), were isolated from the rhizome of Dryopteris crassirhizoma(Aspidiaceae), together with the known kaempferol glycoside, sutchuenoside A(4). The structures of 1-3 were determined as kaempferol 3-α-L-(2, 4-di-O-acetyl)rhamnopyranoside-7-α-L-rhamnopyranoside, kaempferol 3-α-L-(3, 4-di-O-acetyl)rhamnopyranoside-7-α-L-rhamnopyranoside, and kaempferol 3-α-L-(2, 3-di-O-acetyl)rhamnopyranosside-7-α-L-rhamnopyranoside, respectively, by chemical and spectroscopic means. Inhibitory effects of 1-4 and kaempferol on human immunodeficiency virus reverse transcriptase-associated DNA polymerase(RNA-dependent DNA polymerase and DNA-dependent DNA polymerase) and RNase H activities were investigated.
公益社団法人日本薬学会の論文
2001-05-01