Antioxidative Activities of Galloyl Glucopyranosides from the Stem-Bark of Juglans mandshurica
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概要
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Two phenolics, 1,2,6-trigalloylglucose (1) and 1,2,3,6-tetragalloylglucose (2), isolated from the stem-bark of Juglans mandshurica were evaluated for their antioxidative activities. The results showed that compounds 1 and 2 exhibited strong scavenging activities against 1,1′-diphenyl-1-picrylhydrazyl (DPPH), 2,2′-azino-bis-(3-ethylbenzenthiazoline-6-sulphonic) acid (ABTS•+), and superoxide radicals (O2•−), and also had a significant inhibitory effect on lipid peroxidation and low-density lipoprotein (LDL) oxidation. The strong superoxide radical scavenging of 1 and 2 resulted from the potential competitive inhibition with xanthine at the active site of xanthine oxidase (OX). In addition, compounds 1 and 2 displayed significant lipoxygenase inhibitory activity, the mode of inhibition also being identified as competitive. In comparison, the antioxidative activities of compounds 1 and 2, together with gallic acid, indicated that the number of galloyl moieties could play an important role in the antioxidative activity.
- 社団法人 日本農芸化学会の論文
著者
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BAE KiHwan
College of Pharmacy, Chungnam National University
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Thuong Phuong
College Of Pharmacy Chungnam National University
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CHOI Jae
Faculty of Food Science and Biotechnology, Pukyong National University
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Ngoc Tran
College Of Pharmacy Chungnam National University
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HATTORI Masao
Institute of Natural Medicine, University of Toyama
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Min Byung-sun
College Of Pharmacy Catholic University Of Daegu
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HUNG Tran
College of Pharmacy, Chungnam National University
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KIM Jin-Cheon
Korea Research Institute of Chemical Technology
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CHOI Chung-Sig
HansBio
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LEE Joon
College of Pharmacy, Catholic University of Daegu
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