Biotransformation of Pinoresinol Diglucoside to Mammalian Lignans by Human Intestinal Microflora, and lsolation of Enterococcus faecalis Strain PDG-1 Responsible for the Transformation of(+)-Pinoresinol to(+)-Lariciresinol
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概要
- 論文の詳細を見る
By anaerobic incubation of pinoresinol diglucoside (1) from the bark of Eucommia ulmoides with a fecal suspension of humans, eleven metabolites were formed, and their structures were identified as (+)-pinoresinol (2), (+)-lariciresinol (3), 3'-demethyl-(+)-lariciresinol (4), (-)-secoisolariciresinol (5), (-)-3-(3",4"-dihydroxybenzyl)-2-(4'-hydroxy-3'-methoxybenzyl)butane-1,4-diol (6), 2-(3',4'-dihydroxybenzyl)-3-(3",4"-dihydroxybenzyl)butane-1,4-diol (7), 3-(3"-hydroxybenzyl)-2-(4'-hydroxy-3'-methoxybenzyl)butane-1,4-diol (8), 2-(3',4'-dihydroxybenzyl)-3-(3"-hydroxybenzyl)butane-l,4-diol (9), (-)-enterodiol (10), (-)-(2R,3R)-3-(3",4"-dihydroxybenzyl)-2-(4'-hydroxy-3'-methoxybenzyl)butyrolactone (11), (-)-(2R,3R)-2-(3',4'-dihydroxybenzyl)-3-(3",4"-dihydroxybenzyl)butyrolactone (12), (-)-(2R,3R)-3-(3"-hydroxybenzyl)-2-(4'-hydroxy-3'-methoxybenzyl)butyrolactone (13), 2-(3',4'-dihydroxybenzyl)-3-(3"-hydroxybenzyl)butyrolactone (14), 2-(3'-hydroxybenzyl)-3-(3",4"-dihydroxybenzyl)buty-rolactone (15) and (-)-(2R,3R)-enterolactone (16) by various spectroscopic means, including two dimensional (2D)-NMR, mass spectrometry and circular dichroism. A possible metabolic pathway was proposed on the basis of their structures and time course experiments monitored by thin-layer chromatography. Furthermore, a bacterial strain responsible for the transformation of (+)-pinoresinol to (+)-lariciresinol was isolated from a human fecal suspension and identified as Enterococcus faecalis strain PDG-1.
- 社団法人日本薬学会の論文
- 2003-05-01
著者
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DEYAMA Takeshi
Central Research Laboratories, Yomeishu Seizo Co., Ltd
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HATTORI Masao
Institute of Natural Medicine, University of Toyama
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AKAO Teruaki
Faculty of Pharmaceutical Sciences, University of Toyama
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Akao Teruaki
Faculty Of Pharmaceutical Sciences University Of Toyama
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Akao Teruaki
Faculty Of Pharmaceutical Sciences Toyama Medical And Pharmaceutical University
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Akao Teruaki
Graduate School Of Medicine And Pharmaceutical Sciences Univ. Of Toyama
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Akao Teruaki
Department Of Enzymatic Physiology Faculty Of Pharmaceutical Sciences Toyama Medical And Pharmaceuti
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Xie L‐h
Institute Of Natural Medicine Toyama Medical And Pharmaceutical Uniyersity
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XIE Li-Hua
Institute of Natural Medicine, Toyama Medical and Pharmaceutical University
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HAMASAKI Kenjiro
Central Research Laboratories, Yomeishu Seizo Co.Ltd
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Xie Li-hua
Institute Of Natural Medicine Toyama Medical And Pharmaceutical Uniyersity
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Deyama T
Central Research Laboratories Yomeishu Seizo Co. Ltd.
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Deyama Takeshi
Central Research Laboratories Yomeishu Seizo Co. Ltd
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Hattori Masao
Institute Of Natural Medicine Faculty Of Pharmaceutical Sciences
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Hamasaki Kenjiro
Central Research Laboratories Yomeishu Seizo Co.ltd
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Akao Teruaki
Institute Of Natural Medicine Toyama Medical
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