Acteoside as the Analgesic Principle of Cedron (Lippia triphylla), a Peruvian Medicinal Plant

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概要

• 論文の詳細を見る

• Acteoside (verbascoside) was isolated as an analgesic principle from Cedron (leaves and stem of Lippia triphylla (L'HER) O. KUNTZE; Verbenaceae), a Peruvian medicinal plant, by activity-guided separation. The compound exhibited analgesia on acetic acid-induced writhing and on tail pressure pain in mice by the oral administration of 300 mg/kg and 100 mg/kg, respectively. Acteoside also caused weak sedation by its effect on the prolongation of pentobarbital-induced anesthesia and on the depression of locomotion enhanced by methamphetamine. An intravenous injection of acteoside reduced the effective dose to 2 mg/kg by the writhing method. Thirteen related compounds were tested for the activity by intravenous and oral administration to obtain information on the active structure.

• 公益社団法人日本薬学会の論文
• 1997-03-15

著者

• NISHIBE Sansei

  Faculty of Pharmaceutical Sciences, Health Sciences University of Hokkaido

• DEYAMA Takeshi

  Central Research Laboratories, Yomeishu Seizo Co., Ltd

• 山崎 幹夫

  千葉大学薬学部

• 山崎 幹夫

  千葉大学薬学部医薬品素材学講座

• 奥山 恵美

  千葉大学 院薬

• Satake M

  Institute Of Environmental Science For Human Life Ochanomizu University

• SATAKE Motoyoshi

  National Institute of Health Sciences

• OKUYAMA Emi

  Faculty of Pharmaceutical Sciences, Chiba University

• YAMAZAKI Mikio

  Faculty of Pharmaceutical Sciences, Chiba University

• Nishimura H

  Department Of Applied Physics Osaka City University

• Satake Motoyoshi

  Division Of Pharmacognosy Phytochemistry And Narcotics National Institute Of Health Sciences

• Nishimura Hiroaki

  Research Institute, Kagome Company, Ltd.

• Nishimura H

  Kansai Univ. Osaka Jpn

• Okuyama Emi

  Faculty Of Pharmaceutical Science Chiba University

• Maruno Masao

  Research Institute For Biology And Chemistry Tsumura Co. Ltd.

• Nishimura Hiroaki

  Research Institute Kagome Company Ltd.

• Nakamura T

  School Of Pharmaceutical Sciences Mukogawa Women's University

• NAKAMURA Tomonori

  Faculty of Pharmaceutical Sciences, Chiba University

• TSUKADA Atsushi

  Faculty of Pharmaceutical Sciences, Chiba University

• MORIYA Akira

  Central Research Laboratories, Yomeishu Seizo Co., Ltd.,

• Moriya Akira

  Central Research Laboratories Yomeishu Seizo Co. Ltd.

• Tsukada Atsushi

  Faculty Of Pharmaceutical Sciences Chiba University

• Nakamura T

  Department Of Hospital Pharmacy School Of Medicine Kobe University

• OKUYAMA Emi

  Laboratory of Pharmacognosy, Faculty of Pharmaceutical Sciences, Josai International University

• Deyama T

  Central Research Laboratories Yomeishu Seizo Co. Ltd.

• Deyama Takeshi

  Central Research Laboratories Yomeishu Seizo Co. Ltd

• Nishibe Sansei

  Faculty Of Pharmaceutical Sciences Health Science University Of Hokkaido

• Okuyama E

  Laboratory Of Pharmacognosy Faculty Of Pharmaceutical Sciences Josai International University

• Yamazaki Mikio

  Faculty Of Pharmaceutical Sciences Chiba University

• NISHIMURA Hiroaki

  Research Institute for Biology and Chemistry, Tsumura Co., Ltd.,

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