Protective Activity of Geranium Oil and Its Component, Geraniol, in Combination with Vaginal Washing against Vaginal Candidiasis in Mice(Microbiology)
スポンサーリンク
概要
- 論文の詳細を見る
In order to evaluate an effective administration method of essential oils for vaginal candidiasis, efficacy of vaginal application of essential oils against murine experimental candidiasis was investigated. The effect on vaginal inflammation and Candida growth form was also studied. Vaginal candidiasis was established by intravaginal infection of C. albicans to estradiol-treated mice. These mice intravaginally received essential oils such as geranium and tea tree singly or in combination with vaginal washing. Vaginal administration of clotrimazole significantly decreased the number of viable C. albicans cells in the vaginal cavity by itself. In contrast, these essential oils did not lower the cell number. When application of geranium oil or geraniol was combined with vaginal washing, the cell number was decreased significantly. The myeloperoxidase activity assay exhibited the possibility that essential oils worked not only to reduce the viable cell number of C. albicans, but also to improve vaginal inflammation. The smear of vaginal washing suspension suggested that more yeast-form cells appeared in vaginal smears of these oil-treated mice than in control mice. In vitro study showed that a very low concentration (25 μg/ml) of geranium oil and geraniol inhibited mycelial growth, but not yeast growth. Based on these findings, it is estimated that vaginal application of geranium oil or its main component, geraniol, suppressed Candida cell growth in the vagina and its local inflammation when combined with vaginal washing.
- 公益社団法人日本薬学会の論文
- 2008-08-01
著者
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山崎 幹夫
千葉大学薬学部
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Abe Shuichi
山形県立新庄病院
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山崎 幹夫
千葉大学薬学部医薬品素材学講座
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Takeuchi T
Bioresource Laboratories Mercian Corp.
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Takeuchi T
Institute Of Microbial Chemistry
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INOUYE Shigeharu
Teikyo University Institute of Medical Mycology
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YAMAGUCHI Hideyo
Teikyo University Institute of Medical Mycology
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Abe S
Institute Of Medical Mycology Graduate School Of Medical Science Teikyo University
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Abe Shigeru
Departments Of Radiology And Cardiology Yamagata Prefectural Shinjo Hospital
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Abe S
Teikyo Univ. Tokyo Jpn
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Yamaguchi Hideyo
Teikyo Univ. Inst. Of Medical Mycology Tokyo Jpn
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Yamaguchi Hideyo
Departments Of Microbiology And Immunology University Of Teikyo School Of Medicine
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MARUYAMA Naho
Teikyo University Institute of Medical Mycology
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TAKIZAWA Toshio
Teikyo University Institute of Medical Mycology
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ISHIBASHI Hiroko
Teikyo University Institute of Medical Mycology
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HISAJIMA Tatsuya
Teikyo University Institute of Medical Mycology
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ABE Shigeru
Teikyo University Institute of Medical Mycology
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Takizawa Toshio
Teikyo Univ. Inst. Of Medical Mycology
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Takeuchi Toshio
Research And Development Department Kibun Food Chemifa Co. Ltd.
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Mimaki Yoshihiro
Lab. Of Medicinal Plant Sci. School Of Pharmacy Tokyo Univ. Of Pharmacy And Life Sci. Jpn
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Abe S
Japan Poliomyelitis Res. Inst. Tokyo Jpn
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Haraguchi Yuji
Department Of Hygiene And Virology Gunma University School Of Medicine
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Abe Shigeru
Teikyo University Institute Of Medical Mycology And Genome Research Center Teikyo University
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Inouye Shigeharu
Teikyo Univ. Inst. Of Medical Mycology
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Inouye S
Pharmaceutical Research Center Meiji Seika Kaisha Ltd.
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Ishibashi Hiroko
Research Center For Medical Mycology Teikyo University
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Abe Sigeru
Institute Of Medical Mycology Graduate School Of Medical Science Teikyo University
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Yamaguchi Hideyo
Teikyo University Institute Of Medical Mycology Graduate School Of Medical Science Teikyo University
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Abe Shigeru
Teikyo University Institute Of Medical Mycology Graduate School Of Medical Science Teikyo University
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Yamaguchi Hideyo
Teikyo Univ. Inst. Medical Mycology
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Takeuchi T
Inst. Microbial Chemistry Shinagawa‐ku Jpn
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