Inhibitory Effect of Perilla Leaf Extract and Luteolin on Mouse Skin Tumor Promotion
スポンサーリンク
概要
- 論文の詳細を見る
In the present study, the effects of perilla leaf extract (PLE) and luteolin on 7,12-dimethylbenz|o|anthracene (DMBA)- and 12-0-tetradecanoylphorbol-13-acetate (TPA)-induced skin papillomas in mice were investigated. Topical application of PLE prior to TPA treatment in DMBA-initiated mouse skin resulted in a significant reduction in tumor incidence and multiplicity. An even more potent preventive effect was observed with topical application of luteolin, which we previously identified as an antiinflaminatory constituent. PLE was dissolved in drinking water at a 0.05% dose and mice ingested it ad libitum; no significant difference was observed in tumor incidence or multiplicity but there was a significant reduction in tumor volume between the PLE-treated and untreated groups. These results suggest that PLE has potent antipromotion activity and ingesting it as a daily food may provide a beneficial chemopreventive effect.
- 公益社団法人日本薬学会の論文
- 2003-04-01
著者
-
UEDA Hiroshi
Department of Pathology, School of Medicine Gifu University
-
YAMAZAKI Masatoshi
Department of Medical Life Chemistry, Faculty of Pharmaceutical Sciences, Teikyo University
-
山崎 幹夫
千葉大学薬学部
-
Yamazaki M
Department Of Medical Life Chemistry Faculty Of Pharmaceutical Sciences Teikyo University
-
Yamazaki M
School Of Pharmaceutical Sciences Kinki University
-
YAMAZAKI Chikako
Department of Medical Life Chemistry, Faculty of Pharmaceutical Sciences, Teikyo University
-
Yamazaki Masatoshi
Department Of Circulation Research Institute Of Environmental Medicine Nagoya University
-
Ueda H
Natural Medicinal Chemistry Kobe Pharmaceutical University
-
Ueda Hiroshi
Department Of Dermatology Fujita Health University School Of Medicine
-
Yamazaki Chikako
Department Of Medical Life Chemistry Faculty Of Pharmaceutical Sciences Teikyo University
-
Ueda Hiroshi
Department Of Anatomy University Of Occupational And Environmental Health School Of Medicine
-
Ueda Hiroshi
Department Of Anatomy School Of Medicine University Of Occupational And Environmental Health
-
Yamazaki Masatoshi
Department of Cardiovascular Research, Research Institute of Environmental Medicine, Nagoya University
関連論文
- Brazilian Natural Medicines. III. Structures of Triterpene Oligoglycosides and Lipase Inhibitors from Mate, Leaves of Ilex paraguariensis
- Medicinal Flowers. XXVI. Structures of Acylated Oleanane-Type Triterpene Oligoglycosides, Yuchasaponins A, B, C, and D, from the Flower Buds of Camellia oleifera : Gastroprotective, Aldose Reductase Inhibitory, and Radical Scavenging Effects
- Medicinal Flowers. XXI. : Structures of Perennisaponins A, B, C, D, E, and F, Acylated Oleanane-Type Triterpene Oligoglycosides, from the Flowers of Bellis perennis
- Differences in Biological Response Modifier-like Activities According to the Strain and Maturity of Bananas
- Quantitative Thin-Layer Chromatography with a Flame Ionization Detector for Serum Lipid Measurements in the Routine Clinical Laboratory
- Scaling Relation for Excitation Energy under Hyperbolic Deformation(General and Mathematical Physics)
- Medicinal Flowers. XXVII : New Flavanone and Chalcone Glycosides, Arenariumosides I, II, III, and IV, and Tumor Necrosis Factor-α Inhibitors from Everlasting, Flowers of Helichrysum arenarium
- Structures of Acetylated Oleanane-Type Triterpene Saponins, Rarasaponins IV, V, and VI, and Anti-hyperlipidemic Constituents from the Pericarps of Sapindus rarak
- Absolute Stereostructures of Olibanumols A, B, C, H, I, and J from Olibanum, Gum-Resin of Boswellia carterii, and Inhibitors of Nitric Oxide Production in Lipopolysaccharide-Activated Mouse Peritoneal Macrophages
- Medicinal Flowers. XXIV. Chemical Structures and Hepatoprotective Effects of Constituents from Flowers of Hedychium coronarium
- Medicinal Flowers. XXIII. New Taraxastane-Type Triterpene, Punicanolic Acid, with Tumor Necrosis Factor-α Inhibitory Activity from the Flowers of Punica granatum
- Bioactive Constituents from Chinese Natural Medicines. XXXII : Aminopeptidase N and Aldose Reductase Inhibitors from Sinocrassula indica: Structures of Sinocrassosides B_4, B_5, C_1, and D_1-D_3
- Medicinal Foodstuffs. XXXIV. : Structures of New Prenylchalcones and Prenylflavanones with TNF-α and Aminopeptidase N Inhibitory Activities from Boesenbergia rotunda
- Medicinal foodstuffs (33) Gastroprotective principles from Boesenbergia rotunda (zingiberaceae): absolute stereostructures of diels-alder type addition prenylchalcones
- Bioactive Constituents from Chinese Natural Medicines. XXVI : Chemical Structures and Hepatoprotective Effects of Constituents from Roots of Rhodiola sachalinensis
- Bioactive Constituents from Chinese Natural Medicines. XXIV. : Hypoglycemic Effects of Sinocrassula indica in Sugar-Loaded Rats and Genetically Diabetic KK-A^y Mice and Structures of New Acylated Flavonol Glycosides, Sinocrassosides A_1, A_2, B_1, and B_2
- Human single-chain antibody expression in the hemolymph and fat body of silkworm larvae and pupae using BmNPV bacmids
- クサウラベニタケの毒性成分の研究(第2報) : 溶血素の精製と溶血条件の検討
- クサウラベニタケの毒性成分の研究(第1報)生物活性と毒性成分の探索
- Virtual Electrode-induced Spiral Reentry in Ventricular Myocardium Perfused in-vitro
- ファルマシアレビュー : 13年を振り返って
- Apoptosis-Inducing Effects of Sterols from the Dried Powder of Cultured Mycelium of Cordyceps sinensis
- Virtual Electrode Polarization-Induced Reentrant Activity
- A-33 ヒト肝ミクロゾームの薬物代謝能におよぼす Notopterol の影響
- インドネシア産生薬の薬理活性成分に関する研究(第3報)Brucea javanica(L.)MERR.の毒性成分
- インドネシア産生薬の抗拘束水浸ストレス潰瘍活性成分の研究(第1報)Artocarpus integra MERR.(ヒメハラミツ)から(±)-Catechinの単離と同定
- Bioactive Constituents from Chinese Natural Medicines. XXIII. Absolute Structures of New Megastigmane Glycosides, Sedumosides A_4, A_5, A_6, H, and I, and Hepatoprotective Megastigmanes from Sedum sarmentosum
- Bioactive Constituents from Chinese Natural Medicines. XXII. Absolute Structures of New Megastigmane Glycosides, Sedumosides E_1, E_2, E_3, F_1, F_2, and G, from Sedum sarmentosum (Crassulaceae)
- Bioactive Saponins and Glycosides. XXVIII. New Triterpene Saponins, Foliatheasaponins I, II, III, IV, and V, from Tencha (the Leaves of Camellia sinensis)
- PE-010 Moderate Hypothermia Destabilized Spiral Waves without Widening Excitable Gap in Favor of Self-termination of Ventricular Tachycardia/Fibrillation(Arrhythmia, basic(03)(A),Poster Session(English),The 72nd Annual Scientific Meeting of the Japanese C
- Modulation of Spiral Wave Reentry by K^+ Channel Blockade(Mechanisms and Future Challenge)
- PE-330 Concentration-dependent Modification of Spiral-wave Reentry by Verapamil in a Perfused 2-dimensional Layer of Rabbit Ventricular Myocardium(Arrhythmia, basic-4 (A) PE55,Poster Session (English),The 70th Anniversary Annual Scientific Meeting of the
- OE-238 Mechanisms of Global and Regional Cooling-Assisted Defibrillation in a Bidomain Ventricular Model(Arrhythmia, basic-1 (A) OE40,Oral Presentation (English),The 70th Anniversary Annual Scientific Meeting of the Japanese Circulation Society)
- Acute Amiodarone Suppresses Action Potential Alternans in the Two-dimensional Ventricular Myocardium of Rabbit Hearts(Arrhythmia, Basic 4 (A), The 69th Annual Scientific Meeting of the Japanese Circulation Society)
- Chronic Amiodarone Flattens Restitution of Action Potential Duration and Conduction Velocity through the Induction of Postrepolarization Refractoriness(Arrhythmia, Pharmacological Therapy 4 (A), The 69th Annual Scientific Meeting of the Japanese Circulati
- Familial Idiopathic Ventricular Fibrillation Characterized by Increased Dispersion of Ventricular Repolarization and Steep Restitution of the Action Potential Duration(Arrhythmia, Diagnosis/Pathophysiology/EPS 9 (A), The 69th Annual Scientific Meeting of
- Action Potential Dynamics of Spiral-type Reentry in 2-Dimensional Anisotropic Layer of Ventricular Muscle : Optical Mapping Analysis Using High-fidelity CMOS Camera(Arrhythmia, Basic 3 (A), The 69th Annual Scientific Meeting of the Japanese Circulation So
- Anti-oxidant Effects of Kiwi Fruit in Vitro and in Vivo
- Overexpression of bcl-2 Improved Survival of Cos-1 Cells and Enhanced Transient Protein Production
- Exogenous gene expression and growth regulation of hematopoietic cells via a novel human artificial chromosome
- Altered expression of connexin43 contributes to the arrhythmogenic substrate during the development of heart failure in cardiomyopathic hamster
- 1D08 The effect of exercise training and nitric oxide on the glucose-stimulated insulin secretion
- 3P14:The effect of exercise-training on the generation of nitric oxide in pancreatic islet of Langerhans
- 3P11:Effect of single bout exercise on adipocyte lipolysis(II)
- Anti-inflammatory and Anti-allergic Actions by Oral Administration of a Perilla Leaf Extract in Mice(Food & Nutrition Science)
- Construction, Bacterial Expression, and Characterization of Hapten-Specific Single-Chain Fv and Alkaline Phosphatase Fusion Protein
- Truncation of Vargula Lucifersae Still Results in Retention of Luminescence
- Enhancement of Mutation Frequency with Nucleotide Triphosphate Analogs in PCR Random Mutagenesis
- ENHANCED SETTLING OF MAMMALIAN CELLS IN TANKS WITH INCLINED PLATES/SIMULATION BY FLUID MECHANICAL MODEL AND EXPERIMENT
- Beef Tallow, but Not Perilla or Corn Oil, Promotion of Rat Prostate and Intestinal Carcinogenesis by 3,2'-Dimethyl-4-aminobiphenyl
- 1D09 Effect of an acute exercise on the β-adrenergic receptor-adenylate cyclase system in rat adipocytes
- A Hydroxyl Group of Flavonoids Affects Oral Anti-inflammatory Activity and Inhibition of Systemic Tumor Necrosis Factor-α Production
- Inhibitory Effect of Perilla Leaf Extract and Luteolin on Mouse Skin Tumor Promotion
- Luteolin as an Anti-inflammatory and Anti-allergic Constituent of Perilla frutescens
- Anti-tumor Effects of Orally Administered Soft-Shelled Turtle Powder in Mice
- G Protein γ Subunits Coimmunoprecipitated with Antibodies against α Subiunits: Identification of Major Isoforms in Cultureed Cells by Silver Stain and Immunoblotting with Conventional Transfer Procedure
- Effects of Acute Nicotine on Catecholamine Turnover in Various Rat Brain Regions
- ALPHA_2- AND BETA-ADRENOCEPTOR-MEDIATED MODULATION OF NORADRENALINE RELEASE FROM SLICES OF HYPOTHALAMUS AND BRAINSTEM IN SPONTANEOUSLY HYPERTENSIVE RATS
- PRESYNAPTIC REGULATION OF ENDOGENOUS CATECHOLAMINE RELEASE FROM SLICES OF RAT HYPOTHALAMUS-IN SPECIAL REFERENCE TO ROLES OF ADRENALINE
- Cloning and Characterization of Extradiol Aromatic Ring-Cleavage Dioxygenases of Pseudomonas aeruginosa JI104
- Patch test results of topical medicaments for a 5-year duration from April 1993 to March 1998
- Actual conditions of latex allergy in high risk nurses in a Japanese general hospital
- Safety evaluation of Nov lipsticks and foundation cream developed for sensitive skin
- First Cumulant of the Dynamic Structure Factor for Polymers in Θ Solvents. Effects of Chain Stiffness and Local Chain Conformation
- Nuclear Magnetic Relaxation of Oligo- and Poly(α-methylstyrene)s in Dilute Solution
- Dynamic Depolarized Light Scattering by Oligo- and Poly(α-methylstyrene)s in Dilute Solution
- Effects of Cooking Methods of Cabbage on the Production of TNF-α and Induction of Quinone Reductase in Hepa 1c1c7 Cells
- Patch test results of fradiomycin sulfate and gentamicin sulfate and their clinical relevance
- The study on the role of Myocoptes musculinus (kekuidani) on the skin eruptions of the atopic model mice (NC mice)
- Effect of zinc oxide ointment containing nonanoic acid vanillylamide (ZONVA) on the skin eruptions of atopic model mice (NC/F mice)
- Five cases of latex allergy
- Study on diagnostic value of open application test on the eruptive area of fixed drug eruption
- Clinical evaluation of noncomedogenic washing foam (NAF) and lotion (NAL) on acne
- Two cases of contact dermatitis due to metal cannulae
- Hyperpigmentation as a sequela of diphenhydramine contact dermatitis
- Effects of Nifekalant Hydrochrolide on the Spiral-Type Functional Reentry in 2-Dimensional Rabbit Ventricular Myocardium (RIEM Conference Ⅱ, 2003)
- Immunohistochemical Localization of Nitric Oxide Synthase in Normal Human Skin : Expression of Endothelial-type and Inducible-type Nitric Oxide Synthase in Keratinocytes
- Priming Effects of Vegetable Juice on Endogenous Production of Tumor Necrosis Factor
- Mimicry of Erythropoietin and Interleukin-6 Signalling by an Antibody/Cytokine Receptor Chimera in Murine Myeloid 32D Cells
- Antigen-Mediated Genetically Modified Cell Amplification (AMEGA) with Single Vector Transduction
- Selection of Highly Productive Mammalian Cells Based on an Inducible Growth Advantage Using an Antibody/Receptor Chimera
- A Growth Signal with an Artificially Induced Erythropoietin Receptor-gp130 Cytoplasmic Domain Heterodimer
- Importance of a CDR H3 Basal Residue in V_H/V_L Interaction of Human Antibodies
- Teleost Gonadotoropin : Secreting cells and Biological Activities
- The Influence of Domain Structures on the Signal Transduction of Chimeric Receptors Derived from the Erythropoietin Receptor
- Detection of Protein-Protein Interaction by Bioluminescence Resonance Energy Transfer from Firefly Luciferase to Red Fluorescent Protein
- Rapid Homogeneous Immunoassay of Peptides Based on Bioluminescence Resonance Energy Transfer from Firefly Luciferase
- Monitoring of the Refolding Process for Immobilized Firefly Luciferase with a Biosensor Based on Surface Plasmon Resonance
- Refoldin of Firefly Luciferase Immobilized on Agarose Beads
- Construction of Chimeric Proteins between Protein G and Fluorescence-Enhanced Green Fluorescent Protein, and Their Application to Immunoassays
- Restitution Kinetics of Ventricular Action Potential Duration In the Human Heart
- OE-187 Impact of Cilostazol on Angiographic Restenosis after Cobalt-Chromium Alloy Stent Implantation(OE32,Coronary Revascularization, PCI (Restenosis/Others) 2 (IHD),Oral Presentation (English),The 73rd Annual Scientific Meeting of The Japanese Circulati
- Checkered Universe : A Possible Solution to the Galaxy Distribution Problem : Astrophysics and Relativity
- Involvement of G_ in both integrin signal-dependent and -independent pathways regulating endothelin-induced neural progenitor proliferation
- Protein Secretory Patterns during the Development of the Rat Ovary : Reproductive Biology
- Study on Erythrocyte Lipids and Osmotic Fragility in Elderly People with Anemia
- The Effect of Endurance Training on Secreting Adipocyokine
- The Effect of Endurance Training on A-kinase Subtypes in Adipocyte
- Open Sandwich Immunoassay : a Novel Immunoassay Approach Based on the Interchain Interaction of an Antibody Variable Region(MEDICAL BIOTECHNOLOGY)
- Influence of Kiwi Fruit on Immunity and Its Anti-oxidant Effects in Mice