Antidepressant Effects of Apocynum venetum Leaves in a Forced Swimming Test
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概要
- 論文の詳細を見る
An extract of the leaves of Apocynum venetum L.(Apocynaceae)markedly shortenend the immobility time of male rats in a forced swimming test(FST)in a dose range of 30-125mg/kg, indicating a possible antidepressant activity. This effect was comparable to that of the tricyclic antidepressant imipramine(20mg/kg). Neither imipramine(20mg/kg)nor the Apocynum extract in various doses(30, 60, 125mg/kg)produced any overt behavioural change or motor dysfunction in the open field test. This result confirms the assumption that the antidepressant effect of an Apocynum extract in the FST is specific. Further, it can be speculated that this effect might be related to hyperoside and isoquercitrin which are major flavonoids in the extract.
- 公益社団法人日本薬学会の論文
- 2001-07-01
著者
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NISHIBE Sansei
Faculty of Pharmaceutical Sciences, Health Sciences University of Hokkaido
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Uchida Masaru
Tokiwa Phytochemical Co. Ltd.
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Butterweck Veronika
Institute Of Pharmacology And Toxicology Wwu-muenster
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Nishibe S
Faculty Of Pharmaceutical Sciences Health Sciences University Of Hokkaido
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Nishibe Sansei
Faculty Of Pharmaceutical Sciences Health Science University Of Hokkaido
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SASAKI Tsutomu
Tokiwa Phytochemical Co., Ltd.
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Sasaki Tsutomu
Tokiwa Phytochemical Co. Ltd.
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