Inhibition of Cyclic AMP Phosphodiesterase by Lignans and Coumarins of Olea and Fraxinus Barks

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概要

• 論文の詳細を見る

• Studies were conducted on adenosine 3',5'-cyclic monophosphate (cyclic AMP) phosphodiesterase-inhibition by phenolic constituents derived from Olea and Fraxinus barks (Oleaceae), i.e., 38 derivatives of lignans having 2,6-diarylated 3,7-dioxabicyclo[3.3.0]octane ring and 17 derivatives of di- and tri-hydroxylated coumarins. High inhibitory effect was shown on cyclic AMP phosphodiesterase by lignan components of bark of Olea europaea L. and O. africana MILL., (+)-1-acetoxypinoresinol (11) and (+)-1-acetoxypinoresinol-4'-β-D-glucoside (1o), and by coumarin components of bark of Fraxinus japonica BLUME, scopoletin (6b), isofraxidin (7b) and fraxin (7e). The structure-inhibitory activity relationships were also discussed.

• 日本生薬学会の論文
• 1986-03-20

著者

• OHMOTO Taichi

  School of Pharmaceutical Sciences, Toho University

• Sankawa Ushio

  Faculty Of Pharmaceautical Sciences University Of Tokyo

• Nishibe S

  Department Of Pharmacognosy Faculty Of Pharmaceutical Sciences Health Sciences University Of Hokkaid

• Nishibe S

  Higashi Nippon Gakuen Univ. Hokkaido Jpn

• HISADA SUEO

  Faculty of Pharmaceutical Sciences, Higashi Nippon Gakuen University

• Hisada S

  Higashi Nippon Gakuen Univ. Hokkaido

• Hisada Sueo

  Faculty Of Pharmaceutical Sciences Higashi Nippon Gakuen University

• Nikaido Tamotsu

  School Of Pharmaceutical Sciences Toho University

• Nishibe Sansei

  Faculty Of Pharmaceutical Sciences Health Science University Of Hokkaido

• Tsukamoto H

  Higashi Nippon Gakuen Univ. Hokkaido

• TSUKAMOTO HIROKI

  Faculty of Pharmaceutical Sciences, Higashi Nippon Gakuen University

• OHMOTO TAICHI

  School of Pharmaceutical Science, Toho University

• NIKAIDO TAMOTSU

  School of Pharmaceutical Science, Toho University

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