Studies on Constituents of Plantaginis Herba 9 : Inhibitory Effects of Flavonoids from Plantago Herb on HIV-Reverse Transcriptase Activity

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概要

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• The inhibitory effects of flavonoids from Plantago Herb, apigenin, luteolin, cosmosiin, luteolin 7-glucoside, scutellarein, 6-hydroxyluteolin, plantaginin, homoplantaginin and 6-hydroxyluteolin 7-glucoside, on the HIV-reverse transcriptase activity were examined and compared with that of baicalein, a known HIV-reverse transcriptase inhibitor. Their structure-inhibitory activity relationships were discussed. Scutellarein and 6-hydroxyluteolin were shown to be strong HIV-reverse transcriptase inhibitors. The order of inhibitory effects of the test compounds was 6-hydroxyluteolin > scutellarein > baicalein > luteolin. Apigenin showed no inhibitory effect. Both O-glucosylation of 7-hydroxyl group and O-methylation of 6-hydroxyl group on fiavone skeleton caused a decrease in the inhibitory activity, though plantaginin and 6-hydroxyluteolin 7-glucoside showed a potent inhibitory effect on HIV-reverse transcriptase, which is almost equivalent to that of baicalein.

• 日本生薬学会の論文
• 1997-12-20

著者

• Tanaka T

  Gifu Pharmaceutical University

• Nakane Hideo

  Laboratory Of Viral Oncology Aichi Cancer Center Research Institute

• Nishibe Sansei

  Faculty Of Pharmaceutical Sciences Health Science University Of Hokkaido

• Ono Katsuhiko

  Laboratory Of Neural Information National Institute For Physiological Sciences Okazaki National Rese

• Nishibe Sansei

  北海道医療大学 薬

• Noro Yukio

  Faculty Of Pharmacy Meijo University

• Kawamura Tomoko

  Faculty Of Pharmacy Meijo University

• Tanaka Toshihiro

  Faculty Of Pharmaceutical Sciences Health Sciences University Of Hokkaido

• Tanaka Toshihiro

  Gifu College Of Pharmacy

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