Studies on Constituents of Plantaginis Herba 9 : Inhibitory Effects of Flavonoids from Plantago Herb on HIV-Reverse Transcriptase Activity
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概要
- 論文の詳細を見る
The inhibitory effects of flavonoids from Plantago Herb, apigenin, luteolin, cosmosiin, luteolin 7-glucoside, scutellarein, 6-hydroxyluteolin, plantaginin, homoplantaginin and 6-hydroxyluteolin 7-glucoside, on the HIV-reverse transcriptase activity were examined and compared with that of baicalein, a known HIV-reverse transcriptase inhibitor. Their structure-inhibitory activity relationships were discussed. Scutellarein and 6-hydroxyluteolin were shown to be strong HIV-reverse transcriptase inhibitors. The order of inhibitory effects of the test compounds was 6-hydroxyluteolin > scutellarein > baicalein > luteolin. Apigenin showed no inhibitory effect. Both O-glucosylation of 7-hydroxyl group and O-methylation of 6-hydroxyl group on fiavone skeleton caused a decrease in the inhibitory activity, though plantaginin and 6-hydroxyluteolin 7-glucoside showed a potent inhibitory effect on HIV-reverse transcriptase, which is almost equivalent to that of baicalein.
- 日本生薬学会の論文
- 1997-12-20
著者
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Tanaka T
Gifu Pharmaceutical University
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Nakane Hideo
Laboratory Of Viral Oncology Aichi Cancer Center Research Institute
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Nishibe Sansei
Faculty Of Pharmaceutical Sciences Health Science University Of Hokkaido
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Ono Katsuhiko
Laboratory Of Neural Information National Institute For Physiological Sciences Okazaki National Rese
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Nishibe Sansei
北海道医療大学 薬
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Noro Yukio
Faculty Of Pharmacy Meijo University
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Kawamura Tomoko
Faculty Of Pharmacy Meijo University
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Tanaka Toshihiro
Faculty Of Pharmaceutical Sciences Health Sciences University Of Hokkaido
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Tanaka Toshihiro
Gifu College Of Pharmacy
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