A New Subculture and Nematocidal Assay Using a Species of Diplogastridae

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概要

• 論文の詳細を見る

• A new subculture method and a novel microplate assay for nematocidal activity using a species of Diplogastridae have been developed. The assay gives results rapidly, with high sensitivity in 4h, and indicated good correlation between action mechanism and the nematode shape when examining 15 known compounds, including the antiparasitic avermectin, antimalarial quinine, and the γ-amino-n-butyric acid_A (GABA_A) activated Cl^- channel antagonist picrotoxinin. Thus new assay could be used as a primary screening method for new nematocidal compounds.

• 公益社団法人日本薬学会の論文
• 1998-08-15

著者

• KOIKE Kazuo

  School of Pharmaceutical Sciences, Toho University

• NIKAIDO Tamotsu

  School of Pharmaceutical Sciences, Toho University

• Koike K

  Faculty Of Pharmaceutical Sciences Toho University

• Koike Kazuo

  School Of Pharmaceutical Sciences Toho University

• SATOU Tadaaki

  Faculty of Pharmaceutical Science, Toho University

• SATOU Tadaaki

  School of Pharmaceutical Sciences, Toho University

• Satou Tadaaki

  Faculty Of Pharmaceutical Science Toho University

• Watanabe I

  Department Of Pharmacognosy Faculty Of Pharmaceutical Sciences Toho University

• Nikaido Tamotsu

  School Of Pharmaceutical Sciences Toho University

• YANAGIDA Jun

  School of Pharmaceutical Sciences, Toho University

• MATSUHASHI Rinako

  School of Pharmaceutical Sciences, Toho University

• WATANABE Ie

  School of Pharmaceutical Sciences, Toho University

• AKAO Shinkichi

  National Defense Medical College

• Yanagida J

  School Of Pharmaceutical Sciences Toho University

• Matsuhashi Rinako

  Department Of Pharmacognosy Faculty Of Pharmaceutical Sciences Toho University

• NIKAIDO TAMOTSU

  School of Pharmaceutical Science, Toho University

• KOIKE KAZUO

  School of Pharmaceutical Science, Toho University

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