A New Method for Identifying Potential Remedies for Larva Migrans using Crude Drug Extracts (I)

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概要

• 論文の詳細を見る

• Parasitic diseases, which affect many people all over the world, have been studied extensively. However, identification of drug treatments for larva migrans of the dog roundworm, Toxocara canis, has been unsuccessful. In the present study, we conducted in vitro screening of potential treatments for larva migrans infections using a new testing standard that evaluates nematocidal, immunologic enhancement, and cytotoxic activity of the drugs in vitro considering in the targeted host. We examined 36 crude drugs extracted by methanol and water using this evaluation concept. As a result, eight methanol extracts and one water extract at a concentration of 0.1 mg/ml were selected as drug candidates.

• 日本生薬学会の論文
• 2003-02-20

著者

• Akao N

  Section Of Environmental Parasitology Division Of Public Health Graduate School Of Tokyo Medical And

• Akao Nobuaki

  Section Of Environment Parasitology Graduate School Medical And Dental University

• Koike Kazuo

  Faculty Of Pharmaceutical Sciences Toho University

• 二階堂 保

  Faculty of Pharmaceutical Sciences, Toho University

• SATOU Tadaaki

  Faculty of Pharmaceutical Science, Toho University

• Watanabe I

  Department Of Pharmacognosy Faculty Of Pharmaceutical Sciences Toho University

• 二階堂 保

  Faculty Of Pharmaceutical Sciences Toho University

• SATOU Tadaaki

  Department of Pharmacognosy, Faculty of Pharmaceutical Sciences, Toho University

• WATANABE Ie

  Department of Pharmacognosy, Faculty of Pharmaceutical Sciences, Toho University

• NIKAIDO Tamotsu

  Department of Pharmacognosy, Faculty of Pharmaceutical Sciences, Toho University

• Koike Kazuo

  Department Of Geosciences Mining Engineering And Materials Processing Mining College Akita Universit

• Fujita Koichiro

  Section of Environmental Parasitology, Division of Public Health, Graduate School of Tokyo Medical and Dental University

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