Inhibitory Effect of Isoquinoline Alkaloids on Movement of Second-Stage Larvae of Toxocara canis
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概要
- 論文の詳細を見る
To find new anthelmintics against parasites living in host tissues, we used an in vitro assay to screen isoquinoline alkaloids for nematocidal activity on the larva of dog roundworm, Toxocara canis. To evaluate the efficacy of anthelmintics in vitro, Tsuda et al. previously introduced the concept of Relative Mobility (RM) of Toxocara larvae. After improvement of the assay system using image data processing, we generated a new index, RM50, the concentration at which RM=50%. However, except for pyrantel, the RM50 of most existing anthelmintics could not be calculated because of low activity. Of the isoquinoline alkaloids tested, emetine, sanguinarine, 6-methoxydihydrosanguinarine (6-MS), chelerythrine and berberine showed strong nematocidal activities. However, these compounds were highly cytotoxic; thus, the prospect of their direct application is low. We then tested the cytotoxicity (IC50) of other isoquinoline alkaloids in HL60 tissue-culture cells. We continued our search for new anthelmintics by examining in detail the relationship between RM50 and IC50. We determined that an ideal target compound would exhibit a low RM50/IC50 ratio. Allocryptopine, dehydrocorydaline and papaverine were identified as potentially effective anthelmintics.
- 公益社団法人 日本薬学会の論文
- 2002-12-01
著者
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Akao N
Section Of Environmental Parasitology Division Of Public Health Graduate School Of Tokyo Medical And
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Akao Nobuaki
Section Of Environmental Parasitology Graduate School Of Tokyo Medical And Dental University
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Akao Nobuaki
Section Of Environment Parasitology Graduate School Medical And Dental University
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Koike K
Faculty Of Pharmaceutical Sciences Toho University
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Fujita K
Section Of Environmental Parasitology Division Of Public Health Graduate School Of Tokyo Medical And
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二階堂 保
Faculty of Pharmaceutical Sciences, Toho University
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SATOU Tadaaki
Faculty of Pharmaceutical Science, Toho University
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Satou Tadaaki
Faculty Of Pharmaceutical Science Toho University
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二階堂 保
Faculty Of Pharmaceutical Sciences Toho University
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SATOU Tadaaki
Department of Pharmacognosy, Faculty of Pharmaceutical Sciences, Toho University
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KOIKE Kazuo
Department of Pharmacognosy, Faculty of Pharmaceutical Sciences, Toho University
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FUJITA Koichiro
Section of Environmental Parasitology, Division of Public Health, Graduate School of Tokyo Medical a
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NIKAIDO Tamotsu
Department of Pharmacognosy, Faculty of Pharmaceutical Sciences, Toho University
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MATSUHASHI Rinako
Department of Pharmacognosy, Faculty of Pharmaceutical Sciences, Toho University
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MATSUHASHI Rinako
School of Pharmaceutical Sciences, Toho University
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Koike Kazuo
Department Of Mechanical Engineering Tohoku Gakuin University
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Fujita Koichiro
Section Of Environmental Parasitology Department Of Health Development Division Of Public Health Gra
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Matsuhashi Rinako
Department Of Pharmacognosy Faculty Of Pharmaceutical Sciences Toho University
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Koike Kazuo
Department Of Geosciences Mining Engineering And Materials Processing Mining College Akita Universit
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Fujita Koichiro
Section of Environmental Parasitology, Division of Public Health, Graduate School of Tokyo Medical and Dental University
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