Nematocidal Activity of Quassinoids against a Species of Diplogastridae
スポンサーリンク
概要
- 論文の詳細を見る
The nematocidal activity of 38 quassinoids, C_<19> or C_<20> compounds isolated from Simaroubaceae, was measured using a species of Diplogastridae (Nematoda) to develop lead parasiticides. Of the various quassinoids tested, samaderines B and E displayed the most potent nematocidal activity with a minimum lethal concentration (MLC) of 2.0×10^<-5> M. The nematocidal activities of samaderines B and E were 15-fold greater than that of albendazole (3.0×10^<-4> M), 10-fold greater than that of thiabendazole (2.0×10^<-4> M) and 7.5-fold greater than that of avermectin (1.5×10^<-4> M). Thus, samaderines B and E may eventually be used as lead parasiticides. In light of the relationship between the structures of quassinoids and their nematocidal activities, those with potent nematocidal activity may require the elements mentioned. These results should help to further out understanding of nematocidal activity.
- 2000-06-01
著者
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Koike K
Faculty Of Pharmaceutical Sciences Toho University
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SATOU Tadaaki
Faculty of Pharmaceutical Science, Toho University
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Satou Tadaaki
Faculty Of Pharmaceutical Science Toho University
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Watanabe I
Department Of Pharmacognosy Faculty Of Pharmaceutical Sciences Toho University
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二階堂 保
Faculty Of Pharmaceutical Sciences Toho University
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SATOU Tadaaki
Department of Pharmacognosy, Faculty of Pharmaceutical Sciences, Toho University
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KOIKE Kazuo
Department of Pharmacognosy, Faculty of Pharmaceutical Sciences, Toho University
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WATANABE Ie
Department of Pharmacognosy, Faculty of Pharmaceutical Sciences, Toho University
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NIKAIDO Tamotsu
Department of Pharmacognosy, Faculty of Pharmaceutical Sciences, Toho University
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Koike Kazuo
Department Of Mechanical Engineering Tohoku Gakuin University
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Koike Kazuo
Department Of Geosciences Mining Engineering And Materials Processing Mining College Akita Universit
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