Nematocidal Activity of Picrodendrins against a Species of Diplogastridae
スポンサーリンク
概要
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To develop parasiticides, the nematocidal activity of 22 picrotoxane terpenoids, picrodendrins isolated from the Euphorbiaceae plant Picrodendron baccatum (L.) KLUG et URBAN, was measured using a species of Diplogastridae (Nematoda). Picrodendrin P displayed the most potent nematocidal activity with a minimum lethal concentration (MLC) value of 4.4×10^<-3> M. The nematocidal activity of picrodendrin P was 9-fold more potent than that of kainic acid (4.0×10^<-2> M) and santonin (4.0×10^<-2> M) and 6-fold more potent than that of diethylcarbamazine citrate (3.0×10^<-2> M). Thus, picrodendrin P may eventually be used as a leading parasiticide. In light of the relationship between the structure of picrodendrins and their nematocidal activities, potent nematocidal activity was found to require the following elements within the picrotoxane skeleton : the γ-lactone that bridges C-3 and C-5,the epoxide group that bridges between C-6 and C-8,a cis-OCH_3 group and a trans-CH_2OH group related to carbonyl at α-methylene-γ-lactone ring (C-18), and the absence of 4- and 8-hydroxyl groups. These results are the first demonstration of nematocidal activity for these terpenes and thus are important in furthering our understanding.
- 1999-12-15
著者
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Koike K
Faculty Of Pharmaceutical Sciences Toho University
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SATOU Tadaaki
Faculty of Pharmaceutical Science, Toho University
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Satou Tadaaki
Faculty Of Pharmaceutical Science Toho University
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Watanabe I
Department Of Pharmacognosy Faculty Of Pharmaceutical Sciences Toho University
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二階堂 保
Faculty Of Pharmaceutical Sciences Toho University
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SATOU Tadaaki
Department of Pharmacognosy, Faculty of Pharmaceutical Sciences, Toho University
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KOIKE Kazuo
Department of Pharmacognosy, Faculty of Pharmaceutical Sciences, Toho University
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WATANABE Ie
Department of Pharmacognosy, Faculty of Pharmaceutical Sciences, Toho University
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NIKAIDO Tamotsu
Department of Pharmacognosy, Faculty of Pharmaceutical Sciences, Toho University
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Koike Kazuo
Department Of Mechanical Engineering Tohoku Gakuin University
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Koike Kazuo
Department Of Geosciences Mining Engineering And Materials Processing Mining College Akita Universit
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