Pancreatic Lipase-Inhibiting Triterpenoid Saponins from Gypsophila oldhamiana
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概要
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Three new triterpenoid saponins, gypsosaponins A-C (1-3), were isolated from the roots of Gypsophila oldhamiana (Caryophyllaceae). Their structures were established as 3-O-β-D-galactopyranosyl-(1→2)-[β-D-xylopyranosyl-(1→3)]-β-D-glucuronopyranosyl quillaic acid 28-O-α-L-arabinopyranosyl-(1→2)-α-L-arabinopyranosyl-(1→3)-β-D-xylopyranosyl-(1→4)-α-L-rhamnopyranosyl-(1→2)-β-D-fucopyranoside (1), 3-O-β-D-galactopyranosyl-(1→2)-[β-D-xylopyranosyl-(1→3)]-methyl-β-D-glucuronopyranosyl gypsogenin 28-O-β-D-glucopyranosyl-(1→3)-[β-D-xylopyranosyl-(1→4)]-α-L-rhamnopyranosyl-(1→2)-β-D-fucopyranoside (2), and 23-O-β-D-glucopyranosyl gypsogenic acid 28-O-β-D-glucopyranosyl-(1→3)-[β-D-glucopyranosyl-(1→6)]-β-D-glucopyranoside (3), on the basis of various spectroscopic analyses and chemical degradations. The biological activities of 1-3 were examined inhibitory activity against pancreatic lipase, which showed inhibition of 58.2%, 99.2% and 50.3% at concentration of 1 mg/ml, respectively.
- 公益社団法人日本薬学会の論文
- 2007-04-01
著者
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Li Wei
Stevens Institute of Technology
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Li Wei
Faculty Of Pharmaceutical Sciences Toho University
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小池 一男
東邦大・薬
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Li W
Faculty Of Pharmaceutical Sciences Toho University
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Koike K
Faculty Of Pharmaceutical Sciences Toho University
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Koike Kazuo
Toho University School Of Pharmaceutical Sciences
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Koike Kazuo
Faculty Of Pharmaceutical Sciences Toho University
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HAN Likun
Faculty of Environmental and Symbiotic Sciences, Prefectural University of Kumamoto
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ZHENG Quan
Faculty of Pharmaceutical Sciences, Toho University
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HAN Likun
Department of Environmental and Symbiotic Sciences, Prefectural University of Kumamoto
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Li Wei
Department Of Molecular Biology Jilin University
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Li W
Laboratory Of Pharmaceutical Resource Discovery Dalian Institute Of Chemical Physics Chinese Academy
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Han Likun
Faculty Of Environmental And Symbiotic Sciences Prefectural University Of Kumamoto
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Zheng Quan
Faculty Of Pharmaceutical Sciences Toho University
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Koike Kazuo
Faculty Of Business Administration Hosei University
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Li Wei
Faculty Of Metallurgy And Energy Engineering Kunming University Of Science And Technology
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