Tinospinosides D, E, and Tinospin E, Further Clerodane Diterpenoids from Tinospora sagittata

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概要

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• Chemical investigation on the roots of Tinospora sagittata resulted in the isolation of three novel cis-clerodane diterpenoids, tinospinosides D, E, and tinospin E, together with two known compounds, columbin and columbin glucoside, and their structures were determined by extensive spectroscopic analyses, chemical reactions and computer-assisted calculations. The inhibitory activity of the isolated compounds and their chemical derivatives on nitric oxide production in lipopolysaccharide and interferon-γ activited J774.1 macrophage-like cells was also evaluated.

• 公益社団法人　日本薬学会の論文

著者

• Li W

  Faculty Of Pharmaceutical Sciences Toho University

• Huang Chao

  Faculty Of Agriculture Kagawa University

• Asada Yoshihisa

  Faculty Of Pharmaceutical Sciences Tokyo University

• Li Qin

  Laboratory Center, The Fourth Affiliated Hospital, China Medical University

• Koike Kazuo

  Faculty Of Business Administration Hosei University

• Li Wei

  Faculty Of Metallurgy And Energy Engineering Kunming University Of Science And Technology

• Ma Fenghua

  Faculty of Pharmaceutical Sciences, Toho University

• LI Wei

  Faculty of Pharmaceutical Sciences, Toho University

• Huang Chao

  Faculty of Pharmaceutical Sciences, Toho University

• Asada Yoshihisa

  Faculty of Pharmaceutical Sciences, Tokyo University of Science

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